19474-21-6

Upstream product

• 19474-19-2 6β-(2-phenoxy-acetylamino)-penicillanic acid 2,2,2-trichloro-ethyl ester 
• 30199-55-4 1β-oxo-6β-(2-phenoxy-acetylamino)-1λ⁴-penicillanic acid 2,2,2-trichloro-ethyl ester 
• 4888-90-8 phenoxymethylpenicillin sulfoxide 

Downstream Products

• 27124-39-6 (R)-3-methyl-2-((1S)-7-oxo-3-phenoxymethyl-(1rH,5cH)-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-but-3-enoic acid 2,2,2-trichloro-ethyl ester 
• 75994-61-5 10-acetoxy-6β-(2-phenoxy-acetylamino)-penicillanic acid 2,2,2-trichloro-ethyl ester 
• 58849-84-6 3-Methyl-2-[3-oxo-4-(2-phenoxy-acetylamino)-3H-isothiazol-2-yl]-but-2-enoic acid 2,2,2-trichloro-ethyl ester 
• 33695-41-9 3-Methyl-2-[(2-phenoxymethyl-thiazole-4-carbonyl)-amino]-but-3-enoic acid 2,2,2-trichloro-ethyl ester 
• 99346-34-6 (R)-2-[(2R,3R)-2-(4-Methoxy-phenyldisulfanyl)-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-3-methyl-but-3-enoic acid 2,2,2-trichloro-ethyl ester 
• 99346-39-1 (3R,4R)-4-(p-methoxyphenyldithio)-1-<2-methyl-1-(2,2,2-trichloroethoxycarbonyl)prop-1-enyl>-3-phenoxyacetamido-azetidin-2-one 
• 99346-31-3 (R)-3-Methyl-2-[(3R,4R)-2-oxo-3-(2-phenoxy-acetylamino)-4-phenyldisulfanyl-azetidin-1-yl]-but-3-enoic acid 2,2,2-trichloro-ethyl ester 
• 99346-36-8 3-Methyl-2-[(3R,4R)-2-oxo-3-(2-phenoxy-acetylamino)-4-phenyldisulfanyl-azetidin-1-yl]-but-2-enoic acid 2,2,2-trichloro-ethyl ester 
• 99346-33-5 (R)-3-Methyl-2-[(3R,4R)-2-oxo-3-(2-phenoxy-acetylamino)-4-p-tolyldisulfanyl-azetidin-1-yl]-but-3-enoic acid 2,2,2-trichloro-ethyl ester 
• 99346-38-0 (3R,4R)-4-(p-methylphenyl-dithio)-1-<2-methyl-(2,2,2-trichloroethoxycarbonyl)prop-1-enyl>-3-phenoxyacetamido-azetidin-2-one 
• 80303-88-4 (R)-3-Methyl-2-((1S,5R)-7-oxo-3-phenoxymethyl-4-oxa-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-but-3-enoic acid 2,2,2-trichloro-ethyl ester 
• 27250-44-8 (6R)-3-methyl-8-oxo-7c-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
• 27250-43-7 (6R)-3-methyl-8-oxo-7c-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 2,2,2-trichloro-ethyl ester 
• 98381-20-5 2-[(R)-2-Ethoxycarbonylmethyldisulfanyl-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-3-methyl-but-2-enoic acid 2,2,2-trichloro-ethyl ester 

Relevant academic research and scientific papers

OXIDATION STUDIES ON BETA-LACTAM ANTIBIOTICS SYNTHESIS OF PHENAM AND CEPHEM SULFOXIDES AND SULFONES

Penicillin and cephalosporin sulfoxides are conveniently prepared by oxidation of the respective penicillin or cephalosporin in methylene chloride using hydrogen peroxide and acetic acid.Replacement of the acetic acid by formic acid produces the respectiv

Novel esterifying agents, and their production and use

A process for esterifying organic carboxylic acids which comprises reacting an organic carboxylic acid with a carbonic acid ester of the formula: EQU1 wherein R is an organic group and X and Y are each a negative group in the presence of a basic substance to make esterified the carboxyl group in the organic carboxylic acid. The process is advantageous in affording the objective carboxylic ester in a good yield within a short time by a simple operation under a mild reaction condition.