1156-50-9

Usage

Uses

Used in Chemical Synthesis:
BIS(4-NITROPHENYL) SULFONE is used as a precursor in the synthesis of various organic compounds, pharmaceuticals, and dyes. Its unique chemical structure allows it to be a key component in the creation of a wide array of products.
Used in Polymer Industry:
In the polymer industry, BIS(4-NITROPHENYL) SULFONE is utilized as a crosslinking agent. This application enhances the strength and durability of polymers, making them suitable for a broader range of uses.
Used in Plastics and Rubbers:
BIS(4-NITROPHENYL) SULFONE also serves as a stabilizer in plastics and rubbers, improving their resistance to degradation and extending their service life. Its high thermal stability and resistance to oxidation are particularly beneficial in these applications.

InChI:InChI=1/C12H8N2O6S/c15-13(16)9-1-5-11(6-2-9)21(19,20)12-7-3-10(4-8-12)14(17)18/h1-8H

Upstream product

• 1849-36-1 para-nitrobenzenethiol 
• 15959-31-6 sodium 4-nitrobenzenesulfinate 
• 71-43-2 benzene 
• 100-00-5 4-chlorobenzonitrile 
• 139-66-2 diphenyl sulfide 
• 586-78-7 para-nitrophenyl bromide 
• 636-98-6 p-nitrobenzene iodide 
• 1223-31-0 bis(4-nitrophenyl)sulfide 
• 1774-38-5 4,4'-dinitrodiphenyl sulfoxide 
• 30388-70-6 2,2'-dinitrophenyl sulphoxide 
• 100-32-3 di(p-nitrophenyl) disulfide 

Downstream Products

• 77-46-3 acedapsone 
• 36679-41-1 4,4'-bis(N,O-diacetylhydroxylamino)diphenyl sulfone 
• 119-59-5 4,4'-sulfinyldianiline 
• 115166-72-8 bis-{4-[(N-acetyl-sulfanilyl)-amino]-phenyl}-sulfone 
• 383-29-9 bis(p-fluorophenyl)sulfone 
• 100-32-3 di(p-nitrophenyl) disulfide 
• 1223-31-0 bis(4-nitrophenyl)sulfide 
• 74236-92-3 4-Nitro-benzenethiosulfonic acid; compound with ammonia 
• 80-08-0 dapsone 
• 36679-40-0 dapsone dihydroxylamine 
• 1948-92-1 4-(4-nitrophenylsulfonyl)aniline 

Relevant academic research and scientific papers

An efficient method for the oxidation of sulfides to sulfones

Ruthenium trichloride - sodium periodate is a highly efficient and powerful system for the oxidation of unreactive sulfides to sulfones.

Synthesis of symmetrical diaryl sulfone by homocoupling of sodium arylsulfinate

An efficient practical homocoupling reaction of sodium arylsulfinate promoted by Cu(II) is reported whereby symmetrical diaryl sulfone derivatives are obtained with high selectivity and reactivity by intermolecular cross-coupling. This homocoupling reacti

Selective synthesis of sulfoxides and sulfones by methyltrioxorhenium-catalyzed oxidation of sulfides with hydrogen peroxide

Methyltrioxorhenium-catalyzed oxidation of sulfides with hydrogen peroxide in ethanol has been found to be an efficient catalytic system for the selective formation of sulfoxides and sulfones. The oxidation using an equimolar amount of hydrogen peroxide afforded sulfoxides in excellent yield, and the use of two molar amounts of hydrogen peroxide gave sulfones quantitatively. Strongly deactivated sulfide, bis(4-nitrophenyl) sulfide, was converted smoothly to the corresponding sulfoxide and sulfone in excellent yields. The functional group in the side chain of sulfide such as a carbon-carbon double bond was not affected under the reaction conditions, and the sulfur atom was selectively oxidized.

Tris(hydroxymethyl)aminomethane modified layered double hydroxides greatly facilitate polyoxometalate intercalation

Polyoxometalate (POM) intercalation to layered double hydroxides (LDHs) has been greatly restricted by the geometry, charge and size of POMs. We report herein, for the first time, the intercalation of Na3[PW12O40]·15H2O into tris(hydroxymethyl)-aminomethane (Tris) modified layered double hydroxides (Tris-LDH-CO3) using an ion exchange method, resulting in the formation of novel intercalated Tris-LDH-PW12 under ambient conditions without the necessity of degassing CO2. Theoretical calculations show the decreased energy and the slightly distorted LDH layer after Tris modification, indicating that the Tris-modified LDH layers greatly facilitate the intercalation of PW12. Further application of Tris-LDH-PW12 for oxygenation of sulfides shows highly efficient and selective catalytic activities under mild conditions. The Tris-LDH-PW12 can be easily recovered and reused for more than 10 times without any obvious decrease of reactivity. This opens a completely new pathway for engineering POM-LDH advanced functional materials. This journal is

Synthetic method of diarylsulfone compound

The invention relates to a synthetic method of a diarylsulfone compound. The method is characterized in that a copper complex and aryl sulfonyl hydrazide are dissolved in an organic solvent, air serves as an oxidizing agent, a reaction is conducted at the room temperature, separation and purification are conducted to obtain the corresponding diarylsulfone compound, the molar ratio of the copper complex to the aryl sulfonyl hydrazide is (0.01-0.03):1.0, and the reaction time is 2-5 h. Compared with the prior art, the synthesis process provided by the invention has excellent selectivity and highyield, the catalyst copper complex in the reaction can catalyze the self-coupling of aryl sulfonyl hydrazide to synthesize the diarylsulfone compound at room temperature, and the reaction has the characteristics of mild and simple conditions, wide substrate range, convenient product separation, high reaction efficiency and the like.

An Efficient Oxidation of Sulfides to Sulfones with Urea-Hydrogen Peroxide in the Presence of Phthalic Anhydride in Ethyl Acetate

A metal-free, environmentally benign oxidation of substituted sulfides directly to their corresponding sulfones is described. Using urea-hydrogen peroxide and phthalic anhydride in ethyl acetate clean conversion into the sulfone was achieved without observation of the possible sulfoxide oxidation product.

PROCESS FOR THE PREPARATION OF SULFONAMIDE COMPOUNDS

Process for the preparation of known sulfonamides having antibacterial activity applicable on industrial scale, which allows their production in high yields and purity, comprising in particular the step of nucleophile aromatic substitution and oxidation in suitable conditions.

TAPC-promoted oxidation of sulfides and deoxygenation of sulfoxides

Figure presented. 1,3,5-Triazo-2,4,6-triphosphorine-2,2,4,4,6,6- tetrachloride (TAPC) was found to be an efficient promoter for the oxidation of sulfides and deoxygenation of sulfoxides. Excellent yields, short reaction time, easy and quick isolation of the products, solvent-free process, and excellent chemoselectivity are the main advantages of this procedure.

Oxidation kinetics of some sulfoxides with N,N-dibromobenzene sulfonamide

The kinetics of oxidation of some sulfoxides with dibromamine-B yielding sulfones was investigated in presence of HgII, and the rate equation, kobs = k3K2K′h[S]/[RNH 2] + K′h was found to be valid. The reaction involves two distinct pathways namely initial fast step and a subsequent slow step. The chloride ions have no effect on the reactivity of sulfoxides. Sulfoxides containing electron-attracting substituents retard the reactivity while those containing electron-releasing constituents accelerate the rate of oxidation. Exner plot confirms the operation of same mechanism in all the sulfoxides studied. Electrophilic addition of Br+ to sulfur atom results in an electron-deficient sulfonium centre which decomposes in a slow rate-limiting step. The rate coefficients are treated in terms of multiparametric extensions of the Hammett equation to have more insight into the mechanistic aspects.

Chromium(VI) oxide catalyzed oxidation of sulfides to sulfones with periodic acid

A highly efficient and selective oxidation of sulfides to sulfones with periodic acid catalyzed by CrO3 is described. A variety of electron-rich and electron-deficient sulfides were oxidized to sulfones with 2 mol% CrO3 in acetonitrile at room temperature in excellent yields. Sulfides with other readily oxidized functional groups were selectively oxidized to sulfones in high yields with 10 mol% CrO3 in ethyl acetate/acetonitrile at -35 °C.