194980-10-4

Upstream product

• 2791-84-6 L-glutamic acid dibenzyl ester 4-toluenesulfonate 
• 186532-64-9 2-(2,3,4,6-tetra-O-benzyl-α-D-mannopyranosyl)acetic acid 
• 98920-46-8 (2R,3R,4R,5R,6R)-2-(acetoxymethyl)-6-allyltetrahydro-2H-pyran-3,4,5-triyl triacetate 
• 4163-65-9 per-O-acetyl-α-D-mannopyranose 
• 122920-03-0 2,6-Anhydro-7,8,9-trideoxy-D-glycero-D-manno-non-8-enitol 
• 100-39-0 benzyl bromide 
• 120520-79-8 2-(2,3,4,6-tetra-O-benzyl-α-D-mannopyranosyl)ethyl aldehyde 
• 82659-59-4 3-(2,3,4,6-tetra-O-benzyl-α-D-mannopyranosyl)propene 

Relevant academic research and scientific papers

Small molecules as structural and functional mimics of sialyl Lewis X tetrasaccharide in selectin inhibition: A remarkable enhancement of inhibition by additional negative charge and/or hydrophobic group

Several sialyl Lewis X (SLe(X))) mimics that contain the essential functional groups for receptor interaction and a negative charge or a hydrophobic group have been developed as inhibitors of E-, P-, and L-selectins. Some of the mimics exhibit selectin in

C-mannose derivatives as potent mimics of sialyl Lewis X

The synthesis of five sialyl Lewis X mimetics was described. Mimetics 2-6 were easily synthesized from readily available starting materials. Mimics 4 and 6 showed activities five-fold better than sialyl Lewis X. Copyright (C) 1996 Elsevier Science Ltd.