196203-17-5

Upstream product

• 1829-81-8 N-(4-nitrophenyl)benzenesulfonamide 
• 105-36-2 ethyl bromoacetate 
• 98-09-9 benzenesulfonyl chloride 
• 100-01-6 4-nitro-aniline 

Downstream Products

• 196203-06-2 N-4-bromo-phenylsulfonyl-4-[4-(4-tert-butyloxycarbonylpiperazin-1-yl)-phenylamino-carbonyl]-aniline 
• 117309-45-2 [(4-Amino-phenyl)-benzenesulfonyl-amino]-acetic acid 
• 196203-98-2 [(4-Amino-phenyl)-benzenesulfonyl-amino]-acetic acid ethyl ester 

Relevant academic research and scientific papers

Fibrinogen receptor antagonists

Fibrinogen receptor antagonists of the general formula: and which includes, for example, the compounds of formula STR1 are useful for inhibiting the binding of fibrinogen to blood platelets, inhibiting the aggregation of blood platelets, treating thrombus formation or embolus formation, and preventing thrombus or embolus formation.

N- and 2-Substituted N-(Phenylsulfonyl)glycines as Inhibitors of Rat Lens Aldose Reductase

A variety of N-(phenylsulfonyl)-N-phenylglycines 5, N-(phenylsulfonyl)-2-phenylglycines 6, and N-(phenylsulfonyl)anthranilic acids 7 were prepared as analogues of the N-(phenylsulfonyl)glycine 1 aldose reductase inhibitors.In the rat lens assay, several derivatives of 5 display greater inhibitory activity than the corresponding glycines 1, suggesting that N-phenyl substitution enhances affinity for aldose reductase.Enzyme kinetic evaluations of the 4-benzoylamino analogues of 5 and 1 demonstrate that these compounds produce inhibition by the same mechanism.However, the significant differences in relative inhibitory potencies between compounds of series 5 and 1 may indicate that these compounds do not interact with the inhibitor binding site in precisely the same manner.Evaluation of the individual enantiomers of series 6 reveals that the S isomers are substantially more active than the corresponding R isomers.Also, with the exception of the naphthalene analogue 6n, the S stereoisomers of this series display greater inhibitory potencies than the glycines 1.The anthranilates 7 generally are less active than the glycines 1, demonstrating that direct incorporation of an aromatic ring in the glycine side chain may result in a decrease in affinity for aldose reductase.