1829-81-8

Basic information

• Product Name: N-(4-Nitrophenyl)benzenesulfonaMide, 97%
• Synonyms: N-(4-Nitrophenyl)benzenesulfonaMide, 97%;Benzenesulfonamide, N-(4-nitrophenyl)-;N-p-Nitro-phenyl-benzene-sulfonamide
• CAS NO: 1829-81-8
• Molecular Formula: C₁₂H₁₀N₂O₄S
• Molecular Weight: 278.2838
• Mol File: 1829-81-8.mol
• Article Data: 22

Chemical Properties

• Boiling Point: 463.7°Cat760mmHg
• Flash Point: 234.3°C
• Appearance: /
• Density: 1.461g/cm³
• Vapor Pressure: 8.87E-09mmHg at 25°C
• Refractive Index: 1.656
• CAS DataBase Reference: N-(4-Nitrophenyl)benzenesulfonaMide, 97%(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-Nitrophenyl)benzenesulfonaMide, 97%(1829-81-8)
• EPA Substance Registry System: N-(4-Nitrophenyl)benzenesulfonaMide, 97%(1829-81-8)

Safety Data

• Hazardous Substances Data: 1829-81-8(Hazardous Substances Data)

Usage

General Description

N-(4-Nitrophenyl)benzenesulfonamide, 97% is a chemical compound used in various industrial and laboratory applications. It is a white to off-white crystalline solid with a purity of 97%. N-(4-Nitrophenyl)benzenesulfonaMide, 97% is known for its use as a reagent in organic synthesis, particularly in the preparation of sulfonamides and other pharmaceutical intermediates. It is also utilized as a dye intermediate and in the manufacturing of rubber chemicals. Additionally, N-(4-Nitrophenyl)benzenesulfonamide, 97% is used in the production of agrochemicals and as a component in the synthesis of polymer materials. Due to its versatility and wide range of applications, this chemical is in high demand in the chemical industry.

InChI:InChI=1/C12H10N2O4S/c15-14(16)11-8-6-10(7-9-11)13-19(17,18)12-4-2-1-3-5-12/h1-9,13H

Upstream product

• 1678-25-7 N-phenylbenzenesulfonamide 
• 67-66-3 chloroform 
• 134305-16-1 N-chloro-N-phenylbenzenesulphonamide 
• 93352-59-1 N-nitroso-benzenesulfonanilide 
• 64-17-5 ethanol 
• 134899-71-1 N-{1-[(E)-4-Methoxy-phenylimino]-ethyl}-N-(4-nitro-phenyl)-benzenesulfonamide 
• 134899-53-9 N-{1-[(E)-4-Chloro-phenylimino]-ethyl}-N-(4-nitro-phenyl)-benzenesulfonamide 
• 134899-57-3 N-(4-Nitro-phenyl)-N-{1-[(E)-phenylimino]-ethyl}-benzenesulfonamide 
• 100-01-6 4-nitro-aniline 
• 98-09-9 benzenesulfonyl chloride 

Downstream Products

• 117199-39-0 C₆H₅SO₂N(C₆H₄NO₂)AuP(C₆H₅)3 
• 36071-24-6 4-benzenesulfonylamino-benzenediazonium-betaine 
• 6658-72-6 4-benzenesulfonylamino-benzenediazonium; chloride 
• 134305-23-0 N-(1-methyl-1H-pyrrol-2-yl)-N-(4-nitrophenyl)benzenesulphonamide 
• 86785-43-5 2'-chloro-4'-(bromoacetamido)benzenesulfonanilide 
• 86785-32-2 2-chloro-N¹-(phenylsulfonyl)-N⁴-(bromoacetyl)benzoquinone diimine 
• 86785-39-9 4'-(bromoacetamido)benzenesulfonanilide 
• 86785-28-6 N¹-(phenylsulfonyl)-N⁴-(bromoacetyl)benzoquinone diimine 
• 196203-98-2 [(4-Amino-phenyl)-benzenesulfonyl-amino]-acetic acid ethyl ester 
• 117309-45-2 [(4-Amino-phenyl)-benzenesulfonyl-amino]-acetic acid 
• 33964-02-2 benzenesulfonic acid-(2.4.6-trinitro-anilide) 
• 196203-17-5 N-4-nitrophenyl-N-phenylsulfonylglycine ethyl ester 
• 134305-18-3 N-chloro-N-(4-nitrophenyl)benzenesulphonamide 
• 312-63-0 N-(4-fluorophenyl)benzenesulfonamide 

Relevant articles and documents

Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds

Targeting the protein-protein interaction (PPI) between nuclear factor erythroid 2-related factor 2 (Nrf2) and Kelch-like ECH-associated protein 1 (Keap1) is a potential therapeutic strategy to control diseases involving oxidative stress. Here, six classes of known small-molecule Keap1-Nrf2 PPI inhibitors were dissected into 77 fragments in a fragment-based deconstruction reconstruction (FBDR) study and tested in four orthogonal assays. This gave 17 fragment hits of which six were shown by X-ray crystallography to bind in the Keap1 Kelch binding pocket. Two hits were merged into compound 8 with a 220-380-fold stronger affinity (Ki = 16 μM) relative to the parent fragments. Systematic optimization resulted in several novel analogues with Ki values of 0.04-0.5 μM, binding modes determined by X-ray crystallography, and enhanced microsomal stability. This demonstrates how FBDR can be used to find new fragment hits, elucidate important ligand-protein interactions, and identify new potent inhibitors of the Keap1-Nrf2 PPI.

Probing 2H-Indazoles as Templates for SGK1, Tie2, and SRC Kinase Inhibitors

The broader and systematic application of a novel scaffold is often hampered by the unavailability of a short and reliable synthetic access. We investigated a new strategy for the design and synthesis of an array of N2-substituted aza-2H-indazole derivatives as potential kinase inhibitors. Guided by a rational ligand alignment approach to qualify the so-far underrepresented aza-2H-indazole scaffold, indazoles were connected at the N2 position with a phenyl spacer and an arylsulfonamide or amide linkage. Initial profiling against a panel of 30 kinases confirmed the in silico predicted selectivity bias. A synthesized focused library of 52 different aza-2H-indazole derivatives showed good initial selective inhibition against SGK1, Tie2, and SRC kinases, with the best representatives having IC50 values in the range of 500 nm. In a comparative computational study, these data were analyzed and rationalized in light of docking studies.

METHODS OF INHIBITING BACTERIAL VIRULENCE AND COMPOUNDS RELATING THERETO

The present invention relates to compounds and methods for the treatment of bacterial infections. Because their mechanism of action does not involve killing of bacteria or inhibiting their growth, the potential for these compounds to induce drug resistance in bacteria is minimized. Through inhibiting bacterial virulence, the present invention provides a novel means of treating bacterial infections.