1963-21-9Relevant articles and documents
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Katakai,R. et al.
, p. 327 - 329 (1972)
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Synthesis of dendritic oligo(aryl sulfone)s as supports for synthesis
Taylor, Paul C.,Wall, Michael D.,Woodward, Peter R.
, p. 12314 - 12322 (2007/10/03)
A short, divergent route to G1 oligo(aryl sulfone)s and a G 2 oligo(aryl sulfone) dendrimer using nucleophilic aromatic substitution reactions is described. A range of tetrasubstituted pentasulfones are proposed for applications as homogeneous supports for synthesis. Key to achieving selectivity in the syntheses is the activation of leaving groups by sulfide to sulfone oxidation. Preparation of the G2 oligo(aryl sulfone) is low-yielding due to competition from SET processes that are interesting from a mechanistic point of view. The utility of the supports is exemplified with a four step synthesis of a dipeptide and by 'react and release' synthesis of amides.
Polypeptide, DNA fragment encoding the same, drug composition containing the same and process for producing the same
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, (2008/06/13)
This invention particularly provides a novel polypeptide having high protease-inhibiting activity, preferably FXa-inhibiting activity, which comprises, at least as a part of the polypeptide, an amino acid sequence resulting from substitution of an amino acid for at least one amino acid in the following amino acid sequence (1), wherein the amino acid substitution is at least one substitution selected from the following substitution means (i) to (iii). It also provides a process for the production of the polypeptide, a novel DNA fragment encoding the polypeptide and a drug composition containing the same. Amino acid sequence (1) STR1 (i) Substitution of 15 position Gln counting from the N-terminus by an amino acid other than Gln. (ii) Substitution of 42 position Tyr counting from the N-terminus by an amino acid other than Tyr. (iii) Substitution of 7 position Arg counting from the N-terminus by an amino acid other than Arg.