16323-12-9

Basic information

• Product Name: [(methoxythioxomethyl)thio]acetic acid
• Synonyms: [(methoxythioxomethyl)thio]acetic acid
• CAS NO: 16323-12-9
• Molecular Formula: C₄H₆O₃S₂
• Molecular Weight: 166.21864
• EINECS: 240-398-5
• Mol File: 16323-12-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 301.8°Cat760mmHg
• Flash Point: 136.3°C
• Appearance: /
• Density: 1.451g/cm³
• Vapor Pressure: 0.00024mmHg at 25°C
• Refractive Index: 1.6
• CAS DataBase Reference: [(methoxythioxomethyl)thio]acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: [(methoxythioxomethyl)thio]acetic acid(16323-12-9)
• EPA Substance Registry System: [(methoxythioxomethyl)thio]acetic acid(16323-12-9)

Safety Data

• Hazardous Substances Data: 16323-12-9(Hazardous Substances Data)

Usage

General Description

[(Methoxythioxomethyl)thio]acetic acid, also known as methoxythioxomethylthioacetic acid, is a chemical compound with the formula C4H6O3S2. It is a thiolactic acid derivative and is commonly used in the pharmaceutical and agricultural industries as an intermediate in the synthesis of various drugs and crop protection products. [(methoxythioxomethyl)thio]acetic acid is known for its thioxomethyl and thioacetic acid functional groups, which give it potential applications in organic synthesis and as a building block for constructing more complex molecules. Additionally, [(methoxythioxomethyl)thio]acetic acid is considered to be a versatile reagent for the preparation of various thioesters and thioacetic acid derivatives for use in pharmaceutical research and development.

InChI:InChI=1/C4H6O3S2/c1-7-4(8)9-2-3(5)6/h2H2,1H3,(H,5,6)

Upstream product

• 67-56-1 methanol 
• 75-15-0 carbon disulfide 
• 79-08-3 bromoacetic acid 
• 7748-25-6 potassium chloroacetate 
• 3926-62-3 sodium monochloroacetic acid 
• 124-41-4 sodium methylate 
• 79-11-8 chloroacetic acid 

Downstream Products

• 19692-07-0 methyl imidothiocarbamate 
• 20184-99-0 (acetylamino)thiocarbamic acid O-methyl ester 
• 90437-18-6 N'-benzyl-hydrazinecarbothioic acid O-methyl ester 
• 90437-17-5 N-Benzyl-hydrazinecarbothioic acid O-methyl ester 
• 20184-98-9 Methyl-3-phenyl-thiocarbazat 

Relevant articles and documents

Bifunctional 2-(alkoxycarbonothioylthio)acetic acids for the synthesis of TiO2-poly(vinyl acetate) nanocomposites via RAFT polymerization

Reversible addition-fragmentation chain-transfer (RAFT) polymerization has been known as a convenient method for the synthesis of polymers of designed molecular structures. Of particular interest are bifunctional or multifunctional chain-transfer agents (CTAs) which could be employed in the development of advanced materials via RAFT polymerization. In the present study, four bifunctional 2-(alkoxycarbonothioylthio) RAFT CTAs with i￡ COOH functionalities containing methoxy, ethoxy, isopropoxy, and octyloxy groups, respectively, were synthesized and characterized by FTIR and NMR spectroscopy. Polymerizations of vinyl acetate using these CTAs exhibited increased molecular weight with consumption of monomer and relatively narrow dispersities, indicative of living polymerization behavior. The effect of the concentration of 2-(ethoxycarbonothioylthio) acetic acid on the polymerization was examined, revealing that higher concentration of CTA led to lower molecular weight and narrower dispersity. As an example of the application of the synthesized bifunctional CTAs, TiO2-poly(vinyl acetate) (PVAc) nanocomposites were synthesized via a one-pot process and characterized by TGA, DSC, TEM, and affinity test, suggesting attachment of PVAc onto the nano-TiO2 particles. Copyright