197015-32-0Relevant articles and documents
ORGANIC ELECTROLUMINESCENT DEVICE
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Paragraph 0190-0191, (2020/12/30)
Disclosed is an organic electroluminescent device that employs a compound represented by Formula A-1 or A-2: and a compound represented by Formula B: The organic electroluminescent device has excellent luminescent properties such as high color purity and long lifetime.
Preparation method of phenylboronic acid half ester
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Paragraph 0010; 0014, (2020/06/09)
The invention discloses a preparation method of phenylboronic acid half ester. The structural formula of the phenylboronic acid half ester prepared by the method is shown in the specification. The method is mild in reaction condition, the raw materials ar
Construction of spirofused tricyclic frameworks by NHC-catalyzed intramolecular stetter reaction of a benzaldehyde tether with a cyclic exsnone
Hsu, Day-Shin,Cheng, Chiao-Yun
, p. 10832 - 10842 (2019/09/30)
Various benzaldehyde tethers with a cyclic enone were prepared from commercially available 2-hydroxybenzaldehydes via a three-step sequence involving triflate formation, Sonogashira cross-coupling, and regioselective hydrogenation. These substrates were t
Pd(II)-catalyzed one-pot, three-step route for the synthesis of unsymmetrical acridines
Guo, Hai-Ming,Mao, Run-Ze,Wang, Qiao-Tian,Niu, Hong-Ying,Xie, Ming-Sheng,Qu, Gui-Rong
supporting information, p. 5460 - 5463 (2013/11/19)
Unsymmetric acridines are synthesized via a one-pot amination/cyclization/ aromatization reaction for the first time. With Pd(OAc)2-X-Phos as the catalyst, a series of unsymmetric acridines are obtained in moderate to excellent yields (up to 99
Synthesis and SAR of novel benzoxaboroles as a new class of β-lactamase inhibitors
Xia, Yi,Cao, Kathy,Zhou, Yasheen,Alley,Rock, Fernando,Mohan, Manisha,Meewan, Maliwan,Baker, Stephen J.,Lux, Sarah,Ding, Charles Z.,Jia, Guofeng,Kully, Maureen,Plattner, Jacob J.
experimental part, p. 2533 - 2536 (2011/05/15)
A new class of benzoxaborole β-lactamase inhibitors were designed and synthesized. 6-Aryloxy benzoxaborole 22 inhibited AmpC P99 and CMY-2 with K i values in the low nanomolar range. Compound 22 restored antibacterial activity of ceftazidime against Enterobacter cloacae P99 expressing AmpC, a class C β-lactamase enzyme. The SAR around the arylbenzoxaboroles, which included the influence of linker and substitutions was also established.
NAPHTHYLACETIC ACIDS
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Page/Page column 73-74, (2010/06/15)
The invention is concerned with the compounds of formula (I) and pharmaceutically acceptable salts and esters thereof, wherein X, Q, and R1-R6 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula (I) as well as pharmaceutical compositions containing such compounds. The compounds of formula (I) are antagonists or partial agonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.
BORON-CONTAINING SMALL MOLECULES
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Page/Page column 72, (2012/06/05)
This invention relates to, among other items, 6-substituted benzoxaborole compounds and their use for treating bacterial infections.
Electronic control of product distribution in the [5+5]-coupling of ortho-alkynylbenzaldehyde derivatives and γ,δ-unsaturated carbene complexes
Camacho-Davila, Alejandro,Gamage, Lalith S.R.,Wang, Zhipeng,Herndon, James W.
supporting information; experimental part, p. 4954 - 4960 (2010/08/19)
The coupling of highly oxygenated ortho-alkynylbenzaldehyde derivatives with γ,δ-carbene complexes was evaluated systematically. In all of the electron-rich systems investigated the exclusive product of the reaction is the dihydrophenanthrene derivative.
Synthesis and biological evaluations of P4-benzoxaborole-substituted macrocyclic inhibitors of HCV NS3 protease
Ding, Charles Z.,Zhang, Yong-Kang,Li, Xianfeng,Liu, Yang,Zhang, Suoming,Zhou, Yasheen,Plattner, Jacob J.,Baker, Stephen J.,Liu, Liang,Duan, Maosheng,Jarvest, Richard L.,Ji, Jingjing,Kazmierski, Wieslaw M.,Tallant, Matthew D.,Wright, Lois L.,Smith, Gary K.,Crosby, Renae M.,Wang, Amy A.,Ni, Zhi-Jie,Zou, Wuxin,Wright, Jon
scheme or table, p. 7317 - 7322 (2011/01/12)
We disclose here a series of P4-benzoxaborole-substituted macrocyclic HCV protease inhibitors. These inhibitors are potent against HCV NS3 protease, their anti-HCV replicon potencies are largely impacted by substitutions on benzoxaborole ring system and P2 groups. P2 2-thiazole-isoquinoline provides best replicon potency. The in vitro SAR studies and in vivo PK evaluations of selected compounds are described herein.