19734-35-1

Usage

Uses

Used in Pharmaceutical Research:
N-(1-Methyl-2-pyrrolidinylidene)-p-toluenesulfonamide is used as a research compound for studying the effects of muscarinic antagonists on biological systems. It helps in understanding the physiological and pathological functions of muscarinic receptors in the body.
Used in Neurodegenerative Disease Treatment:
In the Pharmaceutical Industry, N-(1-Methyl-2-pyrrolidinylidene)-p-toluenesulfonamide is used as a potential therapeutic agent for the treatment of neurodegenerative diseases such as Alzheimer's and Parkinson's. It targets muscarinic receptor dysfunction, which plays a role in the development and progression of these diseases.

InChI:InChI=1/C12H16N2O2S/c1-10-5-7-11(8-6-10)17(15,16)13-12-4-3-9-14(12)2/h5-8H,3-4,9H2,1-2H3/b13-12-

Upstream product

• 22954-75-2 2-(chlorosulfonylimino)-1-methylpyrrolidine 
• 108-88-3 toluene 
• 70-55-3 toluene-4-sulfonamide 
• 39650-82-3 2,2-dimethoxy-1-methylpyrrolidine 
• 872-50-4 1-methyl-pyrrolidin-2-one 
• 120-94-5 1-Methylpyrrolidine 
• 941-55-9 4-toluenesulfonyl azide 
• 98-59-9 p-toluenesulfonyl chloride 
• 7544-76-5 N-methyl-2-iminopyrrolidine 

Relevant academic research and scientific papers

Air-Induced One-Pot Synthesis of N-Sulfonylformamidines from Sulfonyl Chlorides, NaN3, and Tertiary/Secondary Amines

An efficient and practical one-pot strategy for the synthesis of N-sulfonylformamidines was developed by directly using easily available sulfonyl chlorides, sodium azide and tertiary/secondary amines in the presence of 5 mol-% CuBr2 under aerob

N -Sulfonyl acetylketenimine as a highly reactive intermediate for the synthesis of N -sulfonyl amidines

A highly reactive intermediate N-sulfonyl acetylketenimine was generated from a 3-butyn-2-one participating CuAAC/ring-opening method. Its high reactivity due to bearing two EWGs allowed us to offer the first example of a reaction between ketenimine and amide to synthesize N-sulfonyl amidines efficiently.

Synthesis of N-Sulfonyl Amidines and Acyl Sulfonyl Ureas from Sulfonyl Azides, Carbon Monoxide, and Amides

A Pd-catalyzed and ligand-free carbonylation/cycloaddition/decarboxylation cascade synthesis of sulfonyl amidines from sulfonyl azides and substituted amides at low CO pressure is reported. The reaction proceeds via an initial Pd-catalyzed carbonylative generation of sulfonyl isocyanates from sulfonyl azides, followed by a [2 + 2] cycloaddition with amides and subsequent decarboxylation, which liberates the desired sulfonyl amidines, generating N2 and CO2 as the only reaction byproducts. Using this simple protocol, a diverse range of sulfonyl amidines was obtained in moderate to excellent yields. In addition, the reaction can also be directed through a more conventional amidocarbonylation pathway by employing N-monosubstituted amide nucleophiles to afford acyl sulfonyl ureas in good yields.

CuCI/CCI4-Promoted Convenient Synthesis of Sulfonyl Amidines from Tertiary Amines and Sulfonyl Azides

Chemical Equation Presentation Promoted by CuCI/CCI4, a variety of sulfonyl azides and tertiary amines were successfully coupled to give sulfonyl amidine derivatives in good to excellent yields. A possible mechanism for this reaction Is discussed