19734-35-1

Basic information

• Product Name: N-(1-Methyl-2-pyrrolidinylidene)-p-toluenesulfonamide
• Synonyms: N-(1-Methyl-2-pyrrolidinylidene)-p-toluenesulfonamide;4-Methyl-N-(1-methyl-2-pyrrolidinylidene)benzenesulfonamide
• CAS NO: 19734-35-1
• Molecular Formula: C₁₂H₁₆N₂O₂S
• Molecular Weight: 252.33
• Mol File: 19734-35-1.mol
• Article Data: 6

Chemical Properties

• Melting Point: 157-159℃
• Boiling Point: 388.3°Cat760mmHg
• Flash Point: 188.6°C
• Appearance: /
• Density: 1.24
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.597
• CAS DataBase Reference: N-(1-Methyl-2-pyrrolidinylidene)-p-toluenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(1-Methyl-2-pyrrolidinylidene)-p-toluenesulfonamide(19734-35-1)
• EPA Substance Registry System: N-(1-Methyl-2-pyrrolidinylidene)-p-toluenesulfonamide(19734-35-1)

Safety Data

• Hazardous Substances Data: 19734-35-1(Hazardous Substances Data)

Usage

General Description

The chemical N-(1-Methyl-2-pyrrolidinylidene)-p-toluenesulfonamide, also known as RC-3095, is a compound that is used as a cholinergic agent and a potent muscarinic antagonist. It is commonly used in research and experimental studies to study the effects of muscarinic antagonists on biological systems. This chemical has been shown to have potential applications in the treatment of diseases such as Alzheimer's and Parkinson's, where muscarinic receptor dysfunction plays a role in the development and progression of the disease. Additionally, it has also been used as a tool in understanding the physiological and pathological functions of muscarinic receptors in the body.

InChI:InChI=1/C12H16N2O2S/c1-10-5-7-11(8-6-10)17(15,16)13-12-4-3-9-14(12)2/h5-8H,3-4,9H2,1-2H3/b13-12-

Upstream product

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• 872-50-4 1-methyl-pyrrolidin-2-one 
• 941-55-9 4-toluenesulfonyl azide 
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Relevant articles and documents

Air-Induced One-Pot Synthesis of N-Sulfonylformamidines from Sulfonyl Chlorides, NaN3, and Tertiary/Secondary Amines

An efficient and practical one-pot strategy for the synthesis of N-sulfonylformamidines was developed by directly using easily available sulfonyl chlorides, sodium azide and tertiary/secondary amines in the presence of 5 mol-% CuBr2 under aerob

Synthesis of N-Sulfonyl Amidines and Acyl Sulfonyl Ureas from Sulfonyl Azides, Carbon Monoxide, and Amides

A Pd-catalyzed and ligand-free carbonylation/cycloaddition/decarboxylation cascade synthesis of sulfonyl amidines from sulfonyl azides and substituted amides at low CO pressure is reported. The reaction proceeds via an initial Pd-catalyzed carbonylative generation of sulfonyl isocyanates from sulfonyl azides, followed by a [2 + 2] cycloaddition with amides and subsequent decarboxylation, which liberates the desired sulfonyl amidines, generating N2 and CO2 as the only reaction byproducts. Using this simple protocol, a diverse range of sulfonyl amidines was obtained in moderate to excellent yields. In addition, the reaction can also be directed through a more conventional amidocarbonylation pathway by employing N-monosubstituted amide nucleophiles to afford acyl sulfonyl ureas in good yields.

Synthesis of novel N-(1-methylazacarbocycl-2-ylidene)-sulfamides and -sulfonamides as potential hypoglycemic agents

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