19738-89-7Relevant academic research and scientific papers
A new solid acid catalyst FeCl3/bentonite for aldol condensation under solvent-free condition
Muthuvel,Dineshkumar,Thirumurthy,Rajasri,Thirunarayanan
, p. 252 - 260 (2017/01/18)
For the first time, a new solid acid catalyst has been used for the synthesis of aryl chalcones under solvent free conditions. A simple method (solid dispersion method) has been adopted for the synthesis of FeCl3/bentonite. The prepared catalyst has been characterized by different characterization techniques. A series of E-1-(substituted phenyl)-3-(1-pyrenyl)-2-propen-1-ones have been synthesized using FeCl3/bentonite under microwave-assisted solvent-free conditions. The yields are in the range from 80 to 88%. All the synthesized chalcones have been characterized by their physical constants, analytical, IR, 1H and 13C NMR spectral data. This catalyst can be reused for further runs (after fifth cycle) without decrease in activity. This catalyst gives excellent yields and is inexpensive and easily recyclable for this reaction.
Synthesis and pharmacological evaluation of some new fluorine containing hydroxypyrazolines as potential anticancer and antioxidant agents
Dinesha,Viveka, Shivapura,Priya, Bolli Keerthi,Pai, K. Sreedhara Ranganath,Naveen, Shivalingegowda,Lokanath, Neratur K.,Nagaraja, Gundibasappa Karikannar
, p. 25 - 32 (2015/10/12)
Breast cancer is probably the most prevalent cancer in women. The development of resistance to therapeutic agents and lack of targeted therapy for breast cancer cells provide motivation to identify new compounds for the treatment. With this objective in m
Synthesis and screening of antimicrobial activity of novel 2,5-dimethylpyrrolyl-pyrazole derivatives
Hallikeri,Joshi, Shrinivas D.,Kulkarni
, p. 157 - 160 (2019/01/16)
A new series of 2,5-dimethylpyrrolyl-pyrazole derivatives (5a-g) was synthesized by refluxing a mixture of substituted chalcones in ethanol with 4-(2,5-dimethylpyrrol- 1-yl) benzoic acid hydrazide. Purity of newly synthesized compounds was confirmed by TLC and melting point. The structures of all newly synthesized compounds were confirmed by spectral study such as FTIR, 1H NMR and Mass spectroscopy. The compounds were screened for their antimicrobial and antitubercular activities using broth microdilution and MABA methods respectively.
Preheated fly-ash catalyzed aldol condensation: Efficient synthesis of chalcones and antimicrobial activities of some 3-thienyl chalcones
Arulkumaran, Ranganathan,Vijayakumar, Sambandhamoorthy,Sakthinathan, S. Pazhanivel,Kamalakkannan, Dakshnamoorthy,Ranganathan, Kaliyaperumal,Suresh, Ramamoorthy,Sundararajan, Rajasekaran,Vanangamudi, Ganesan,Thirunarayanan, Ganesamoorthy
, p. 1684 - 1690 (2013/09/24)
In the present study we have prepared a series of some chalcones using solvent - free Aldol - condensation by microwave irradiation. The yields of the ketones are more than 60%. The synthesised chalcones were characterized by their analytical, physical and spectral data. The antimicrobial activities of substituted styryl 3-thienyl ketones have been studied using Bauer-Kirby method.
Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP
Cox, Christopher D.,Breslin, Michael J.,Mariano, Brenda J.,Coleman, Paul J.,Buser, Carolyn A.,Walsh, Eileen S.,Hamilton, Kelly,Huber, Hans E.,Kohl, Nancy E.,Torrent, Maricel,Yan, Youwei,Kuo, Laurence C.,Hartman, George D.
, p. 2041 - 2045 (2007/10/03)
Optimization of high-throughput screening (HTS) hits resulted in the discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of KSP. Dihydropyrazole 15 is a potent, cell-active KSP inhibitor that induces apoptosis and generates aberrant mitotic spindles in human ovarian carcinoma cells at low nanomolar concentrations. X-ray crystallographic evidence is presented which demonstrates that these inhibitors bind in an allosteric pocket of KSP distant from the nucleotide and microtubule binding sites.
