197644-80-7

Upstream product

• 32934-24-0 ethyl 2,3,4,6-tetra-O-acetyl-1-thio-β-D-glucopyranoside 
• 100-39-0 benzyl bromide 
• 197644-79-4 (2'S,3'S)-ethyl 3,4-di-O-(2',3'-dimethoxybutane-2',3'-diyl)-1-thio-β-D-glucopyranoside 

Downstream Products

• 197644-81-8 (2S,3S)-3-O-[2',6'-di-O-benzyl-3',4'-di-O-(2,3-dimethoxybutane-2,3-diyl)-α-D-glucopyranosyl]-1,2-O-isopropylidene-5-O-tert-butyldiphenylsilyl-α-D-ribofuranoside 
• 302332-13-4 (3R,5S,7R,8R,9S,10R)-10-Benzyloxy-7-benzyloxymethyl-3,8,9-trihydroxy-1,6-dioxaspiro[4.5]decane 3,8,9-tris(di-O-benzyl)phosphate 
• 302332-14-5 (3S,5S,7R,8R,9S,10R)-10-Benzyloxy-7-benzyloxymethyl-3,8,9-trihydroxy-1,6-dioxaspiro[4.5]decane 3,8,9-tris(di-O-benzyl)phosphate 
• 302332-07-6 (3R,5S,7R,8R,9S,10R,2'S,3'S)-10-Benzyloxy-7-benzyloxymethyl-8,9-di-O-(2',3'-dimethoxy-2',3'-diyl)-3-hydroxy-1,6-dioxaspiro[4.5]decane 
• 302332-09-8 (3S,5S,7R,8R,9S,10R,2'S,3'S)-10-Benzyloxy-7-benzyloxymethyl-8,9-di-O-(2',3'-dimethoxy-2',3'-diyl)-3-hydroxy-1,6-dioxaspiro[4.5]decane 

Relevant academic research and scientific papers

Synthesis of potent agonists of the D-myo-inositol 1,4,5-trisphosphate receptor based on clustered disaccharide polyphosphate analogues of adenophostin A

Clustered disaccharide analogues of adenophostin A (2), i.e. mono-, di-, and tetravalent derivatives 6-8, respectively, were synthesized and evaluated as novel ligands for the tetrameric D-myo-inositol 1,4,5-trisphosphate receptor (IP3R). The s

Synthesis of clustered disaccharide polyphosphate analogues of adenophostin A

Three new potential ligands for the IP3 receptor (i.e. compounds 5-7) were prepared by Sonogashira coupling of propargyl 2-O-acetyl-5-O-benzyl-3-O-(3,4-di-O-acetyl-2,6-di-O-benzyl-α-D-glucopyranosyl) -β-D-ribofuranoside (15) with iodobenzene, 1,2-diiodobenzene and 1,2,4,5-tetraiodobenzene, followed by deacetylation, phosphorylation and deprotection.