197644-81-8

Upstream product

• 190970-10-6 1,2-O-isopropylidene-5-O-tert-butyldiphenylsilyl-α-D-ribofuranose 
• 197644-80-7 (2'S,3'S)-ethyl 2,6-di-O-benzyl-3,4-di-O-(2',3'-dimethoxybutane-2',3'-diyl)-1-thio-β-D-glucopyranoside 
• 100-39-0 benzyl bromide 
• 32934-24-0 ethyl 2,3,4,6-tetra-O-acetyl-1-thio-β-D-glucopyranoside 
• 197644-79-4 (2'S,3'S)-ethyl 3,4-di-O-(2',3'-dimethoxybutane-2',3'-diyl)-1-thio-β-D-glucopyranoside 

Downstream Products

• 197644-82-9 (2S,3S)-5-O-benzyl-3-O-[2',6'-di-O-benzyl-3',4'-di-O-(2,3-dimethoxybutane-2,3-diyl)-α-D-glucopyranosyl]-1,2-O-isopropylidene-α-D-ribofuranoside 
• 197644-83-0 1,2-di-O-acetyl-3-O-(3',4'-di-O-acetyl-2',6'-di-O-benzyl-α-D-glucopyranosyl)-5-O-benzyl-α/β-D-ribofuranoside 
• 305839-06-9 2'-O-acetyl-3'-O-(3'',4''-di-O-acetyl-2'',6''-di-O-benzyl-α-D-glucopyranosyl)-5'-azido-N⁶-benzoyl-5'-deoxyadenosine 
• 305839-08-1 5'-azido-N⁶-benzoyl-3'-O-(2'',6''-di-O-benzyl-α-D-glucopyranosyl)-5'-deoxyadenosine 
• 305839-02-5 5-azido-5-deoxy-3-O-{2,6-di-O-benzyl-3,4-di-O-[(2'S,3'S)-2',3'-dimethoxybutane-2',3'-diyl]-α-D-glucopyranosyl}-1,2-O-isopropylidene-α-D-ribofuranoside 
• 295320-98-8 3-O-[2,6-di-O-benzyl-3,4-O-[(2S,3S)-2,3-dimethoxybutan-2,3-yl]-α-D-glucopyranosyl]-1,2-O-isopropylidene-α-D-ribofuranose 

Relevant academic research and scientific papers

Synthesis of potent agonists of the D-myo-inositol 1,4,5-trisphosphate receptor based on clustered disaccharide polyphosphate analogues of adenophostin A

Clustered disaccharide analogues of adenophostin A (2), i.e. mono-, di-, and tetravalent derivatives 6-8, respectively, were synthesized and evaluated as novel ligands for the tetrameric D-myo-inositol 1,4,5-trisphosphate receptor (IP3R). The s

Synthesis of clustered disaccharide polyphosphate analogues of adenophostin A

Three new potential ligands for the IP3 receptor (i.e. compounds 5-7) were prepared by Sonogashira coupling of propargyl 2-O-acetyl-5-O-benzyl-3-O-(3,4-di-O-acetyl-2,6-di-O-benzyl-α-D-glucopyranosyl) -β-D-ribofuranoside (15) with iodobenzene, 1,2-diiodobenzene and 1,2,4,5-tetraiodobenzene, followed by deacetylation, phosphorylation and deprotection.