1978-37-6

Basic information

• Product Name: 3-FLUORO-N-METHYLANILINE
• Synonyms: 3-FLUORO-N-METHYLANILINE;3-Fluoro-N-methylaniline ,98%;3-Fluoro-N-methylaniline 97%
• CAS NO: 1978-37-6
• Molecular Formula: C₇H₈FN
• Molecular Weight: 125.14
• Product Categories: Amines;C7;Nitrogen Compounds
• Mol File: 1978-37-6.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 94 °C19 mm Hg(lit.)
• Flash Point: 125 °F
• Appearance: /
• Density: 1.1069 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.692mmHg at 25°C
• Refractive Index: n20/D 1.5390(lit.)
• PKA: 4.11±0.25(Predicted)
• CAS DataBase Reference: 3-FLUORO-N-METHYLANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-FLUORO-N-METHYLANILINE(1978-37-6)
• EPA Substance Registry System: 3-FLUORO-N-METHYLANILINE(1978-37-6)

Safety Data

• Hazard Codes: Xn
• Statements: 10-22-41
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 1992 3/PG 3
• WGK Germany: 2
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 1978-37-6(Hazardous Substances Data)

Usage

General Description

3-FLUORO-N-METHYLANILINE is a chemical compound with the formula C7H8FNN. It is a fluorinated aromatic amine that is commonly used in organic synthesis and pharmaceutical research. The molecule contains a fluorine atom, methyl group, and amino group attached to a benzene ring. It is known for its ability to participate in various chemical reactions, including nucleophilic substitution and aromatic electrophilic substitution. 3-FLUORO-N-METHYLANILINE has potential applications in the development of pharmaceuticals, agrochemicals, and other fine chemicals due to its unique properties and reactivity. However, it also poses potential health risks and must be handled with proper caution and safety measures.

InChI:InChI=1/C7H8FN/c1-9-7-4-2-3-6(8)5-7/h2-5,9H,1H3

Upstream product

• 67-56-1 methanol 
• 402-67-5 3-fluoro-1-nitrobenzene 
• 372-19-0 meta-fluoroaniline 
• 68-12-2 N,N-dimethyl-formamide 
• 50-00-0 formaldehyd 
• 74-88-4 methyl iodide 
• 643735-24-4 N-(3-fluorophenyl)-N-methylformamide 
• 1428-10-0 N-(3-fluorophenyl)formamide 

Downstream Products

• 1240693-61-1 C₁₈H₁₁F₄N₃O 
• 1356668-60-4 N-(3-fluorophenyl)-N-methylmethacrylamide 
• 1248590-81-9 N-(3-fluorophenyl)-N-methyl-1H-indazol-6-amine 
• 1248587-69-0 N-(3-fluorophenyl)-N-methyl-1H-pyrrolo[2,3-b]pyridin-6-amine 
• 1009562-41-7 2-bromo-N-(3-fluorophenyl)-N-methylacetamide 
• 1040284-51-2 N-methyl-N-(3-fluorophenyl)isonicotinamide 
• 113734-41-1 N-methyl-N-p-fluorobenzyl-m-fluoroaniline 
• 676628-04-9 6-[(3-fluoro-phenyl)-methyl-amino]-4-isopropyl-N-(tetrahydro-pyran-4-ylmethyl)-nicotinamide 
• 226411-05-8 N'-<1-(4-N-benzyl-N-methylamino-2-fluorophenyl)-2-propyl>-N,N-dibenzylglycinamide 
• 226411-04-7 2-chloro-N-<1-(4-N-methyl-N-benzylamino-2-fluorophenyl)-2-propyl>acetamide 
• 226411-14-9 [4-(2-amino-propyl)-3-fluoro-phenyl]-benzyl-methyl-amine 

Relevant articles and documents

Selective N -monomethylation of primary anilines with the controllable installation of N -CH2D, N -CHD2, and N -CD3units

The selective N-monomethylation of primary anilines was realized by the use of the Me3N-BH3/N,N-dimethylformamide (DMF) system as the methyl source. This method also allows for the controllable introduction of N-CH2D, N-CHD2, and N-CD3 units with high lev

Rhodium(iii)-catalyzed indole synthesis at room temperature using the transient oxidizing directing group strategy

Rh-catalyzed reactions of N-alkyl anilines with internal alkynes at room temperature have been developed using an in situ generated N-nitroso group as a transient oxidizing directing group. Due to mild reaction conditions, this method enabled synthesis of a broad range of N-alkyl indoles, including even two indole-based medicinal compounds. Our work disclosed the feasibility of the transient oxidizing directing group strategy in C-H functionalization reactions, which possesses the potential to enhance overall step-economy and impart new reactivity patterns to substrates.