197847-92-0

Basic information

• Product Name: (6-[3-(TRIFLUOROMETHOXY)PHENYL]PYRIDIN-3-YL)METHANOL
• Synonyms: (6-[3-(TRIFLUOROMETHOXY)PHENYL]PYRIDIN-3-YL)METHANOL;6-[3-(TRIFLUOROMETHOXY)PHENYL]-3-PYRIDINEMETHANOL
• CAS NO: 197847-92-0
• Molecular Formula: C₁₃H₁₀F₃NO₂
• Molecular Weight: 269.22
• Mol File: 197847-92-0.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (6-[3-(TRIFLUOROMETHOXY)PHENYL]PYRIDIN-3-YL)METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (6-[3-(TRIFLUOROMETHOXY)PHENYL]PYRIDIN-3-YL)METHANOL(197847-92-0)
• EPA Substance Registry System: (6-[3-(TRIFLUOROMETHOXY)PHENYL]PYRIDIN-3-YL)METHANOL(197847-92-0)

Safety Data

• Hazardous Substances Data: 197847-92-0(Hazardous Substances Data)

Usage

General Description

"(6-[3-(trifluoromethoxy)phenyl]pyridin-3-yl)methanol" is a chemical compound with a molecular structure that consists of a pyridine ring attached to a phenyl ring with a trifluoromethoxy group. The compound also contains a methanol group attached to the pyridine ring. It is a white solid at room temperature and is commonly used in chemical research and development. It has potential applications in pharmaceuticals and agrochemicals due to its structural characteristics and reactivity. (6-[3-(TRIFLUOROMETHOXY)PHENYL]PYRIDIN-3-YL)METHANOL is a valuable tool for scientists and researchers working in the field of chemistry, especially in the development of new drug candidates and pesticides. Further research and studies are ongoing to explore its potential uses and properties.

Upstream product

• 197847-91-9 2-(3-trifluoromethoxyphenyl)-5-carboxy pyridine 
• 7757-82-6 sodium sulfate 
• 149806-06-4 6-bromonicotinaldehyde 
• 179113-90-7 (3-(trifluoromethoxy)phenyl)boronic acid 
• 898796-59-3 6-(3-(trifluoromethoxy)phenyl)nicotinaldehyde 

Downstream Products

• 197847-81-7 1-(2-(3-Trifluoromethoxyphenyl)-pyrid-5-ylmethyl)-5-(4-cyanobenzyl)imidazole 

Relevant articles and documents

Antitubercular and Antiparasitic 2-Nitroimidazopyrazinones with Improved Potency and Solubility

Following the approval of delamanid and pretomanid as new drugs to treat drug-resistant tuberculosis, there is now a renewed interest in bicyclic nitroimidazole scaffolds as a source of therapeutics against infectious diseases. We recently described a nitroimidazopyrazinone bicyclic subclass with promising antitubercular and antiparasitic activity, prompting additional efforts to generate analogs with improved solubility and enhanced potency. The key pendant aryl substituent was modified by (i) introducing polar functionality to the methylene linker, (ii) replacing the terminal phenyl group with less lipophilic heterocycles, or (iii) generating extended biaryl side chains. Improved antitubercular and antitrypanosomal activity was observed with the biaryl side chains, with most analogs achieved 2- to 175-fold higher activity than the monoaryl parent compounds, with encouraging improvements in solubility when pyridyl groups were incorporated. This study has contributed to understanding the existing structure-activity relationship (SAR) of the nitroimidazopyrazinone scaffold against a panel of disease-causing organisms to support future lead optimization.