197852-01-0

Basic information

• Product Name: N-Methyl-3-oxo-3-phenylpropanaMide
• Synonyms: N-Methyl-3-oxo-3-phenylpropanaMide;N-Methyl-b-oxo-benzenepropanamide
• CAS NO: 197852-01-0
• Molecular Formula: C₁₀H₁₁NO₂
• Molecular Weight: 177.19984
• Mol File: 197852-01-0.mol
• Article Data: 3

Chemical Properties

• Melting Point: 80-81 °C
• Boiling Point: 389.7±25.0 °C(Predicted)
• Appearance: /
• Density: 1.108±0.06 g/cm3(Predicted)
• PKA: 11.95±0.23(Predicted)
• CAS DataBase Reference: N-Methyl-3-oxo-3-phenylpropanaMide(CAS DataBase Reference)
• NIST Chemistry Reference: N-Methyl-3-oxo-3-phenylpropanaMide(197852-01-0)
• EPA Substance Registry System: N-Methyl-3-oxo-3-phenylpropanaMide(197852-01-0)

Safety Data

• Hazardous Substances Data: 197852-01-0(Hazardous Substances Data)

Usage

General Description

N-Methyl-3-oxo-3-phenylpropanamide is a chemical compound with the molecular formula C11H13NO2. It is a member of the amide class of organic compounds and is commonly used as a reagent in chemical synthesis. N-Methyl-3-oxo-3-phenylpropanaMide has a methyl group attached to the nitrogen atom, a phenyl group attached to the carbon atom, and a carbonyl group, also known as a ketone functionality, which gives it its "oxo" designation. N-Methyl-3-oxo-3-phenylpropanamide has a wide range of potential applications in pharmaceuticals and as a building block for the synthesis of more complex organic molecules. However, it is important to note that this compound should be handled with caution due to its potential health hazards and should only be used by individuals with proper training and equipment.

Upstream product

• 7732-18-5 water 
• 63947-74-0 C₁₁H₁₁BF₂O₃ 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 114514-93-1 N-Methyl-5-phenyl-isoxazolium-methosulfat 
• 1008-75-9 3-methyl-5-phenylisoxazole 
• 74-89-5 methylamine 
• 614-27-7 methyl 3-oxo-3-phenylpropionate 

Downstream Products

• 76183-10-3 (S)-3-hydroxy-N-methyl-3-phenylpropanamide 
• 24956-49-8 N,2-dimethyl-3-oxo-3-phenylpropanamide 

Relevant articles and documents

Br?nsted Base-Mediated Regio- and Stereoselective trans-Silaboration of Propargylamides: Access to 1,2-Vinylborasilanes

A facile method for the preparation of β-boryl-α-silyl aryl acrylamides using phenyllithium, dimethylphenylsilylpinacolborane, and propargylamides is reported. A key feature of this transition metal-free reaction is the Br?nsted base deprotonation of aryl secondary propargylamide to produce a Lewis base that activates the B?Si bond, which is followed by a sequential intramolecular α-silylation-trans-β-borylation. The reaction proceeds in complete regio- and stereoselectivity. A wide variety of N- and aryl-substituted propargylamides afford trans-1,2-vinylborasilanes in high yield. The vicinal borasilane products undergo a variety of subsequent chemoselective transformations.

The synthesis of a chiral fluoxetine intermediate by catalytic enantioselective hydrogenation of benzoylacetamide

In the presence of a chiral BINAP-ruthenium(II) catalyst, asymmetric hydrogenation of β-keto propanoic acid N-methyl amide under 200 psi of hydrogen pressure furnished the corresponding 3-hydroxypropanoic acid N- methyl amide as the single enantiomer. The