197852-01-0

Usage

Uses

Used in Pharmaceutical Industry:
N-Methyl-3-oxo-3-phenylpropanamide is utilized as an intermediate in the synthesis of various pharmaceutical compounds. Its unique structure, including the ketone functionality and the presence of a phenyl group, makes it a valuable component in the development of new drugs with specific therapeutic properties.
Used in Organic Synthesis:
As a building block in organic synthesis, N-Methyl-3-oxo-3-phenylpropanamide is employed to construct more complex organic molecules. Its versatile chemical properties allow it to be used in a variety of reactions, such as condensation, reduction, and substitution, enabling the creation of a wide range of organic compounds with diverse applications.
Used in Research and Development:
N-Methyl-3-oxo-3-phenylpropanamide serves as a valuable research tool in the field of organic chemistry. It is used to study reaction mechanisms, explore new synthetic routes, and investigate the properties of amide-containing compounds. Its use in research contributes to the advancement of knowledge in organic chemistry and the development of novel synthetic strategies.

Upstream product

• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 74-89-5 methylamine 
• 63947-74-0 C₁₁H₁₁BF₂O₃ 
• 7732-18-5 water 
• 114514-93-1 N-Methyl-5-phenyl-isoxazolium-methosulfat 
• 614-27-7 methyl 3-oxo-3-phenylpropionate 
• 1008-75-9 3-methyl-5-phenylisoxazole 

Downstream Products

• 76183-10-3 (S)-3-hydroxy-N-methyl-3-phenylpropanamide 
• 24956-49-8 N,2-dimethyl-3-oxo-3-phenylpropanamide 

Relevant academic research and scientific papers

Br?nsted Base-Mediated Regio- and Stereoselective trans-Silaboration of Propargylamides: Access to 1,2-Vinylborasilanes

A facile method for the preparation of β-boryl-α-silyl aryl acrylamides using phenyllithium, dimethylphenylsilylpinacolborane, and propargylamides is reported. A key feature of this transition metal-free reaction is the Br?nsted base deprotonation of aryl secondary propargylamide to produce a Lewis base that activates the B?Si bond, which is followed by a sequential intramolecular α-silylation-trans-β-borylation. The reaction proceeds in complete regio- and stereoselectivity. A wide variety of N- and aryl-substituted propargylamides afford trans-1,2-vinylborasilanes in high yield. The vicinal borasilane products undergo a variety of subsequent chemoselective transformations.

Synthesis and Characterization of New Boron Compounds Using Reaction of Diazonium Tetraphenylborate with Enaminoamides

A family of oxazaborines, diazaborinones, triazaborines, and triazaborinones was prepared by reaction of polarized ethylenes, such as β-enaminoamides, with 4-methylbenzenediazo-nium tetraphenylborates. The reaction conditions (stirring in CH2Cl2 at room temperature (Method A) or stirring with CH3COONa in CH2Cl2 at room temperature (Method B) or refluxing in the CH2Cl2/toluene mixture (Method C)) controlled the formation and relative content of these compounds in the reaction mixtures from one to three products. Substituted oxazaborines gradually rearranged into diazaborinones at 250 °C. The prepared compounds were characterized by1H NMR,13C NMR, IR, and UV–Vis spectroscopy, HRMS, or microanalysis. The structure of individual compounds was confirmed by11B NMR,15N NMR, 1D NOESY, and X-ray analysis. The mechanism of reaction of enaminoamides with 4-methylbenzenediazonium tetraphenylborate was proposed.

The synthesis of a chiral fluoxetine intermediate by catalytic enantioselective hydrogenation of benzoylacetamide

In the presence of a chiral BINAP-ruthenium(II) catalyst, asymmetric hydrogenation of β-keto propanoic acid N-methyl amide under 200 psi of hydrogen pressure furnished the corresponding 3-hydroxypropanoic acid N- methyl amide as the single enantiomer. The