198021-41-9

Upstream product

• 1147849-07-7 ethyl [(4S,5R)-4,5-diphenyloxazolidin-2-on-3-yl]acetate 
• 198021-38-4 [(4S,5R)-4,5-diphenyloxazolidin-2-on-3-yl]acetic acid 

Downstream Products

• 1217258-84-8 tert-butyl-2-((3S,4R)-2-oxo-3-((4S,5R)-2-oxo-4,5-diphenyloxazolidin-3-yl)-4-((E)-styryl)azetidin-1-yl)acetate 
• 198021-64-6 (3S,4R)-2-Oxo-3-((4S,5R)-2-oxo-4,5-diphenyl-oxazolidin-3-yl)-4-propyl-azetidine-1-carbaldehyde 
• 198022-19-4 (4S,5R)-3-[(2S,3S)-2-Benzyloxymethyl-1-(bis-trimethylsilanyl-methyl)-4-oxo-azetidin-3-yl]-4,5-diphenyl-oxazolidin-2-one 
• 198022-12-7 (4S,5R)-3-[(3S,4R)-1-(Bis-trimethylsilanyl-methyl)-2-oxo-4-phenethyl-azetidin-3-yl]-4,5-diphenyl-oxazolidin-2-one 
• 198022-11-6 (4S,5R)-3-[(3S,4R)-1-(Bis-trimethylsilanyl-methyl)-2-oxo-4-propyl-azetidin-3-yl]-4,5-diphenyl-oxazolidin-2-one 
• 198021-44-2 (3S,4R)-1-[bis(trimethylsilyl)methyl]-4-methyl-3-[(4S,5R)-4,5-diphenyl-2-oxo-oxazolidin-3-yl]-azetidin-2-one 

Relevant academic research and scientific papers

A practical synthesis of enantiopure 4,4,4-trifluoro-allo-threonine from an easily available fluorinated building block

A practical method to prepare enantiopure 4,4,4-trifluoro-allo-threonine was developed by using an easily available fluorinated building block and a chiral auxiliary as starting materials. Trifluoroacetic anhydride was annulated with a ketene, derived fro

CARBACEPHEM β-LACTAM ANTIBIOTICS

Carbacephem -lactam antibiotics having structure (I) are disclosed, including stereoisomers, pharmaceutically acceptable salts, esters and prodrugs thereof, wherein Ar1, Ar2, R1 and R2 are as defined herein. The compounds are useful for the treatment of bacterial infections, in particular those caused by methicillin-resistant Staphylococcus spp.

CARBACEPHEM BETA-LACTAM ANTIBIOTICS

Carbacephem β-lactam antibiotics having chemical structures (I) and (II) are disclosed: including stereoisomers, pharmaceutically acceptable salts, esters and prodrugs thereof, wherein Ar2, R1, R2 and R6 are as defined herein. The compounds are useful for the treatment of bacterial infections, in particular those caused by methicillin-resistant Staphylococcus spp.

CARBACEPHEM β-LACTAM ANTIBIOTICS

Carbacephem β-lactam antibiotics having the following chemical structures (I) and (II) are disclosed, including stereoisomers, pharmaceutically acceptable salts, esters and prodrugs thereof, wherein Ar2, R1, R2 and R3 are as defined herein. The compounds are useful for the treatment of bacterial infections, in particular those caused by methicillin-resistant Staphylococcus spp.

A contribution to the asymmetric synthesis of 3-amine β-lactams: The diastereoselective [2+2] cycloaddition reaction of chiral aminoketene equivalents with enolizable aldehyde-derived/mines

N-[Bis(trimethylsilyl)methyl]imines 9 show unique chemical properties when compared with conventional imines. Their reaction with optically pure aminoketenes derived from dehydrochlorination of 14 and 15 affords the corresponding 3-amino-4-alkyl-β-lactams