198211-79-9

Usage

Uses

Used in Organic Synthesis:
Boronic acid, (2-methoxy-4-methylphenyl)(9CI) is used as a building block in organic synthesis for the creation of various pharmaceuticals and agrochemicals. Its unique reactivity and properties allow for the formation of reversible covalent bonds with diols, facilitating the synthesis of complex organic molecules.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, Boronic acid, (2-methoxy-4-methylphenyl)(9CI) is utilized for the development of new drugs and therapeutic agents. Its ability to form reversible covalent bonds with diols makes it a valuable tool in drug discovery and optimization processes.
Used in Drug Discovery:
Boronic acid, (2-methoxy-4-methylphenyl)(9CI) is employed as a key component in drug discovery, where its specific reactivity and properties contribute to the identification and development of potential drug candidates. Its interaction with diols allows for the exploration of novel chemical spaces and the generation of new therapeutic agents.
Used in Research Settings:
In research settings, Boronic acid, (2-methoxy-4-methylphenyl)(9CI) is used to study the fundamental chemistry of boronic acids and their interactions with various biological targets. This research helps to expand the understanding of boronic acid chemistry and its potential applications in various fields, including materials science, catalysis, and supramolecular chemistry.
Used in Industrial Settings:
In industrial applications, Boronic acid, (2-methoxy-4-methylphenyl)(9CI) is utilized for the large-scale synthesis of pharmaceuticals and agrochemicals. Its unique properties and reactivity make it an essential component in the production of various commercial products, contributing to the advancement of the chemical industry.

Upstream product

• 150-46-9 triethyl borate 
• 95740-49-1 1-bromo-2-methoxy-4-methylbenzene 
• 39538-68-6 2-methoxy-4-methylaniline 
• 38512-82-2 3-methoxy-4-nitrotoluene 
• 35928-80-4 6-iodo-3-methyl-phenol 
• 186583-59-5 1-iodo-2-methoxy-4-methylbenzene 
• 2835-98-5 2-Hydroxy-4-methylanilin 
• 121-43-7 Trimethyl borate 

Downstream Products

• 1049801-56-0 1-(2-methoxy-4-methylphenyl)cytosine 
• 1049801-61-7 1-(2-methoxy-4-methylphenyl)uracil 
• 1049801-65-1 1-(2-methoxy-4-methylphenyl)thymine 
• 1049801-57-1 9-(2-methoxy-4-methylphenyl)adenine 
• 1379680-52-0 C₃₈H₃₂O₂P₂ 
• 1379680-53-1 C₃₈H₃₂P₂ 
• 1313377-81-9 2-[2-tert-butyl-7-(2-methoxy-4-methylphenyl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]acetic acid 
• 1313377-82-0 2-[2-tert-butyl-7-(2-hydroxy-4-methylphenyl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]acetic acid 
• 1619901-74-4 3-(2-methoxy-4-methylphenyl)-3-methylcyclohexanone 
• 1380434-33-2 2-ethyl-7-(2-methoxy-4-methylphenyl)-3-nitropyrazolo[1,5-a]pyridine 

Relevant academic research and scientific papers

NOVEL ANTIVIRAL COMPOUNDS

The present invention relates to compounds of formula (A) as defined herein having antiviral activity, more specifically HIV (Human Immunodeficiency Virus) replication inhibiting properties. The invention also relates to pharmaceutical compositions comprising an effective amount of such compounds as active ingredients. This invention further relates to the use of such compounds as medicines or in the manufacture of a medicament useful for the treatment of animals suffering from viral infections, in particular HIV infection. This invention further relates to methods for the treatment of viral infections in animals by the administration of a therapeutical amount of such compounds, optionally combined with one or more other drugs having antiviral activity.

Stable axial chirality in metal complexes bearing 4,4′-substituted BIPHEPs: Application to catalytic asymmetric carbon-carbon bond-forming reactions

Not only electronic but also steric effects of 4,4′-substituents in BIPHEP derivatives and metal (Pd, Pt, and Au) complexes are shown to influence the stability of the biphenyl single bond rotation. While electron-donating or sterically demanding substituents on the 4,4′-positions destabilize the axial chirality of BIPHEP derivatives, electron-withdrawing or sterically less demanding ones on the 4,4′-positions stabilize the axis chirality. Particularly, the axial chirality of palladium dichloride complexes bearing BIPHEP with t-Bu and CF3 substituents on the 4,4′-positions is most labile and stable, respectively (ΔG≠ = 29.22 and 30.49 kcal mol-1 at 300 K; t1/2 = 7 and 56 years at 300 K). These enantiopure dicationic BIPHEPPd complexes can be employed for catalytic enantioselective arylation, alkenylation, and ene reactions to give the corresponding products in good-to-excellent yields and enantioselectivities. Significantly, in the carbonyl-ene reaction of trifluoropyruvate with isobutene, the turnover frequency (TOF) reached 58200 h-1. The remarkable effects of 4,4′-substituents in BIPHEP derivatives can be employed as a guiding principle in the design of versatile and efficient ligands.

NOVEL VIRAL REPLICATION INHIBITORS

The present invention relates to a series of novel compounds having antiviral activity, more specifically HIV (Human Immunodeficiency Virus) replication inhibiting properties. The invention also relates to methods for the preparation of such compounds, as well as to novel intermediates useful in one or more steps of such syntheses. The invention also relates to pharmaceutical compositions comprising an effective amount of such compounds as active ingredients. This invention further relates to the use of such compounds as medicines or in the manufacture of a medicament useful for the treatment of animals suffering from viral infections, in particular HIV infection. This invention further relates to methods for the treatment of viral infections in animals by the administration of a therapeutical amount of such compounds, optionally combined with one or more other drugs having antiviral activity.

6-phenyl-pyridin-2-ylamine derivatives

The present invention relates to certain 6-phenyl-pyridin-2-ylamine derivatives that exhibit activity as nitric oxide synthase (NOS) inhibitors, to pharmaceutical compositions containing them and to their use in the treatment and prevention of central nervous system disorders.