198274-48-5

Upstream product

• 143-33-9 sodium cyanide 
• 164513-49-9 2-bromo-1-(bromomethyl)-5-methoxy-3-methylbenzene 
• 874-63-5 3,5-dimethylmethoxybenzene 
• 6267-34-1 2-bromo-5-methoxy-1,3-dimethyl-benzene 

Downstream Products

• 198274-49-6 ethyl (E)-3-[2-(cyanomethyl)-4-methoxy-6-methylphenyl]acrylate 
• 294872-87-0 methyl 3-[2-(cyanomethyl)-4-methoxy-6-methylphenyl]propionate 
• 198274-51-0 methyl 3-{4-methoxy-2-[(methoxycarbonyl)methyl]-6-methylphenyl}propionate 
• 294872-90-5 3-[2-(carboxymethyl)-4-methoxy-6-methylphenyl]propionic acid 

Relevant academic research and scientific papers

Practical Synthesis of the Trisubstituted Naphthalene Carboxylic Acid from Neocarzinostatin Chromophore

Neocarzinostatin carboxylic acid (5) has been synthesized in 33% overall yield by a nine-step sequence which is operationally easy enough to be carried out by second-year chemistry students. 3,5-dimethylanisole was brominated in the para and in one benzyl

Decagram-Scale Synthesis of the Neocarzinostatin Carboxylic Acid

Neocarzinostatin carboxylic acid (2) was synthesized on a 10-g scale in 9 steps and 43% overall yield from 3,5-dimethylanisol (9) (Schemes 5, 7). The hindered bromoarene 23, reached after 3 steps, underwent a high-temperature Heck coupling with ethyl acry