19832-04-3

Basic information

• Product Name: 2-PIPERIDINE ACETIC ACID
• Synonyms: 2-Piperidylacetic Acid;piperidin-2-ylacetic acid(SALTDATA: H2O);)-2-Piperidinylacetic acid;2-(Carboxymethyl)piperidine;2-Piperidinylacetic acid;2-(2-Piperidyl)acetic acid;_x005f\r2-Piperidylacetic Acid
• CAS NO: 19832-04-3
• Molecular Formula: C₇H₁₃NO₂
• Molecular Weight: 143.19
• Mol File: 19832-04-3.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 286.8°Cat760mmHg
• Flash Point: 127.3°C
• Appearance: /
• Density: 1.063g/cm³
• Vapor Pressure: 0.000659mmHg at 25°C
• Refractive Index: 1.465
• CAS DataBase Reference: 2-PIPERIDINE ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PIPERIDINE ACETIC ACID(19832-04-3)
• EPA Substance Registry System: 2-PIPERIDINE ACETIC ACID(19832-04-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 19832-04-3(Hazardous Substances Data)

Usage

General Description

2-Piperidine acetic acid, also known as 2-PAA, is a chemical compound with potential pharmaceutical applications. It is an acetic acid derivative that contains a piperidine ring, which gives it unique properties and potential biological activities. 2-PIPERIDINE ACETIC ACID has been studied for its potential as a central nervous system depressant and an anti-inflammatory agent. It has also been investigated for its potential use in the treatment of Parkinson's disease and other neurological disorders. Research is ongoing to further understand the pharmacological profile and potential therapeutic applications of 2-Piperidine acetic acid.

InChI:InChI=1/C7H13NO2/c9-7(10)5-6-3-1-2-4-8-6/h6,8H,1-5H2,(H,9,10)

Upstream product

• 1484-84-0 2(RS)-(2-hydroxyethyl)piperidine 
• 522-33-8 Tripiperidin 
• 141-82-2 malonic acid 
• 542-05-2 acetonedicarboxylic acid 
• 1369774-33-3 (1R,5R)-9-benzyloxycarbonylamino-2-oxo-1-oxabicyclo[3.3.1]nonane 
• 1369774-32-2 7-benzyloxycarbonylazabicyclo-[3.2.1]octan-6-one 
• 1369774-31-1 (1R,5S,6S)-N-benzyloxycarbonyl-6-tropanol 
• 1369774-30-0 (1R,5S,6R)-6-tropanol 
• 1369774-34-4 (1R,5S,6R)-6-tropanol (R,R)-tartrate 
• 1369774-29-7 6-tropanol 
• 68419-38-5 (2R)-2-(2-methoxyethyl)piperidine 
• 111612-19-2 (1S,4R)-1-<(2R)-2-(3,3-Dimethyl-2-oxo-1-butyl)-1-piperidylcarbonyl>-4,7,7-trimethyl-2-oxa-bicyclo<2.2.1>heptan-3-on 
• 111504-83-7 (1S,4R)-1-(1,2,3,4-Tetrahydro-1-pyridyl-carbonyl)-4,7,7-trimethyl-2-oxa-bicyclo<2.2.1>heptan-3-on 
• 1036403-99-2 (R)-2-[(N-benzyloxycarbonyl)piperidin-2-yl]ethanoic acid 

Downstream Products

• 5562-60-7 1-azabicyclo<4.2.0>octan-8-one 
• 183859-36-1 methyl (+/-)-N-(tert-butyloxycarbonyl)piperidin-2-ylacetate 
• 23692-08-2 piperidin-2-yl-acetic acid methyl ester 
• 460997-31-3 2-[(1-benzyl-6-oxo-1,4,5,6-tetrahydro-pyridin-3-yl)-vinyl]-piperidine-1-carboxylic acid tert-butyl ester 
• 460997-30-2 2-[2-(1-benzyl-6-oxo-1,4,5,6-tetrahydro-pyridin-3-yl)-2-hydroxy-ethyl]-piperidine-1-carboxylic acid tert-butyl ester 
• 460997-29-9 2-[(1-benzyl-6-oxo-1,4,5,6-tetrahydro-pyridin-3-yl)-2-oxo-ethyl]-piperidine-1-carboxylic acid tert-butyl ester 
• 1272321-55-7 2-(1-(tert-butoxycarbonyl)piperidin-2-yl)acetic acid 
• 1036403-99-2 (R)-2-[(N-benzyloxycarbonyl)piperidin-2-yl]ethanoic acid 

Relevant articles and documents

Condensed azetadinones-(2). 1. 1-azabicyclo-4,2,0-octanone-(2)

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Syntheses of (-)-pelletierine and (-)-homopipecolic acid

Enantiomeric syntheses of (-)-homopipecolic acid and (-)-pelletierine have been achieved by chiral resolution of tropanol followed by Baeyer-Villiger oxidation. The methodology provides a practical route for the synthesis of optically pure piperidines. The Royal Society of Chemistry 2012.

Hydroformylation of alkenylamines. Concise approaches toward piperidines, quinolizidines, and related alkaloids

Linear hydroformylation of N-protected allyl- or homoallylamines (cyclohydrocarbonylation: CHC), followed by a reductive amination constitute the two key steps toward convenient routes to aza-heterocycles.

Improved protocol for asymmetric, intramolecular heteroatom Michael addition using organocatalysis: Enantioselective syntheses of homoproline, pelletierine, and homopipecolic acid

(Chemical Equation Presented) An improved protocol for the construction of enantioenriched pyrrolidine, indoline, and piperidine rings using an organocatalyzed, intramolecular heteroatom Michael addition is described. Application to the enantioselective synthesis of homoproline, homopipecolic acid, and pelletierine has been accomplished.