183859-36-1

Basic information

• Product Name: Piperidin-2-yl-acetic acid methyl ester, hydrochloride
• Synonyms: Piperidin-2-yl-acetic acid methyl ester, hydrochloride;tert-Butyl 2-(2-methoxy-2-oxoethyl);VJNWVGAZYYQKTF-UHFFFAOYSA-N
• CAS NO: 183859-36-1
• Molecular Formula: C8H16ClNO2
• Molecular Weight: 193.67114
• Mol File: 183859-36-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 213.1°C at 760 mmHg
• Flash Point: 82.7°C
• Appearance: /
• Density: 0.982g/cm³
• Vapor Pressure: 0.167mmHg at 25°C
• Refractive Index: 1.439
• CAS DataBase Reference: Piperidin-2-yl-acetic acid methyl ester, hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Piperidin-2-yl-acetic acid methyl ester, hydrochloride(183859-36-1)
• EPA Substance Registry System: Piperidin-2-yl-acetic acid methyl ester, hydrochloride(183859-36-1)

Safety Data

• Hazardous Substances Data: 183859-36-1(Hazardous Substances Data)

Usage

General Description

Piperidin-2-yl-acetic acid methyl ester, hydrochloride is a chemical compound that is commonly used in pharmaceutical research. It is a derivative of piperidine, a heterocyclic amine. Piperidin-2-yl-acetic acid methyl ester, hydrochloride is often used in the synthesis of various pharmaceuticals, especially those targeting the central nervous system. The hydrochloride salt form of this compound makes it more stable and easier to handle in laboratory settings. Additionally, it may be used as a precursor in the synthesis of other important chemical compounds. Overall, this chemical plays a crucial role in the development of new pharmaceutical drugs and has various applications in the pharmaceutical industry.

InChI:InChI=1/C8H15NO2/c1-11-8(10)6-7-4-2-3-5-9-7/h7,9H,2-6H2,1H3

Upstream product

• 67-56-1 methanol 
• 19832-04-3 2-(piperidin-2-yl)acetic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 13115-43-0 2-pyridineacetic acid 
• 1484-84-0 2(RS)-(2-hydroxyethyl)piperidine 
• 98303-20-9 1-(tert-butoxycarbonyl)piperidine-2-carboxylic acid 
• 7440-44-0 pyrographite 
• 186581-53-3 diazomethane 
• 149518-50-3 2-(1-(tert-butoxycarbonyl)-2-piperidinyl)acetic acid 
• 118811-03-3 tert-butyl 2-(2-hydroxyethyl)piperidine-1-carboxylate 
• 132910-79-3 (+/-) methyl N-tert-butyloxycarbonyl 2-piperidinecarboxylate 
• 74-95-3 1,1-dibromomethane 
• 19615-30-6 piperidin-2-yl-acetic acid hydrochloride 
• 24153-01-3 piperidin-2-yl-acetic acid methyl ester hydrochloride 

Downstream Products

• 131134-77-5 (S)-2-(methoxycarbonylmethyl)piperidine-1-carboxylic acid tert-butyl ester 
• 813433-73-7 (R)-2-methoxycarbonylmethylpiperidine-1-carboxylic acid tert-butyl ester 
• 118811-03-3 tert-butyl 2-(2-hydroxyethyl)piperidine-1-carboxylate 
• 159898-10-9 (S)-2-{1-[(tert-butoxy)carbonyl]piperidin-2-yl}acetic acid 
• 486-89-5 (+/-)-thermopsine 

Relevant articles and documents

Chemoenzymatic approach to enantiopure piperidine-based β-amino esters in organic solvents

This research concentrates on the enantioselectivities of lipase-catalysed reactions with methyl esters of 2-piperidylacetic acid and 3-piperidinecarboxylic acid derivatives. N-Acetylated 2-piperidylacetic acid methyl ester displayed good enantioselectivi

Kowalski ester homologation. Application to the synthesis of β-amino esters

The Kowalski ester homologation protocol has been applied to a representative range of α-amino esters to provide β-amino esters with excellent levels of enantio- and diastereocontrol. A key feature of this chemistry is the nature of the N-protecting group that is employed.

Antagonists of gonadotropin releasing hormone

PCT No. PCT/US97/08428 Sec. 371 Date Nov. 12, 1998 Sec. 102(e) Date Nov. 12, 1998 PCT Filed May 16, 1997 PCT Pub. No. WO97/44037 PCT Pub. Date Nov. 27, 1997There are disclosed compounds of formula (I) and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related conditions in both men and women.