122059-35-2

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl 1-Benzyl-2-piperidineacetate is used as an intermediate in the synthesis of various drugs for its analgesic and anesthetic properties. It plays a crucial role in the development of medications that can provide pain relief and anesthesia.
Used in Research Applications:
Ethyl 1-Benzyl-2-piperidineacetate is used as a research chemical to study its properties and potential applications in the field of pharmaceuticals. Researchers utilize Ethyl 1-Benzyl-2-piperidineacetate to explore its interactions with biological systems and to develop new drug candidates with improved efficacy and safety profiles.

InChI:InChI=1/C16H23NO2/c1-2-19-16(18)12-15-10-6-7-11-17(15)13-14-8-4-3-5-9-14/h3-5,8-9,15H,2,6-7,10-13H2,1H3

Upstream product

• 100-39-0 benzyl bromide 
• 110326-44-8 2-ethoxyhexahydro-2H-isoxazolo<2,3-a>pyridine 
• 120153-68-6 N-benzylpiperidine-2-carbonitrile 
• 105-36-2 ethyl bromoacetate 
• 110-89-4 piperidine 
• 111710-77-1 ethyl 7-bromo-2-(E)-heptenoate 
• 2905-56-8 N-Benzylpiperidine 
• 29872-25-1 N-benzylpiperidine N-oxide 
• 98202-45-0 ethyl (2E)-7-iodohept-2-enoate 
• 100-46-9 benzylamine 

Downstream Products

• 5562-60-7 1-azabicyclo<4.2.0>octan-8-one 
• 19832-04-3 2-(piperidin-2-yl)acetic acid 
• 486-89-5 (+/-)-anagyrine 
• 890936-76-2 ethyl 2-[N-benzylpiperidin-2-yl]acrylate 

Relevant academic research and scientific papers

Stereocontrolled synthesis and alkylation of cyclic β-amino esters: Asymmetric synthesis of a (-)-sparteine surrogate

A convenient method for the stereoselective synthesis of cyclic β-amino esters from an iodo αβ-unsaturated ester and α-methylbenzylamine is described. Subsequent enolate generation and alkylation proceeds with complete stereocontrol, with the two stereogenic centres working together. In this way, a functionalised piperidine suitable for alkaloid natural product synthesis was prepared. The usefulness of the methodology is exemplified with the concise synthesis of a (-)-sparteine surrogate. The Royal Society of Chemistry.

A New and Practical Procedure for the Bruylants Reaction. Zinc-Mediated Synthesis of Tertiary Homoallylamines and β-Aminoesters

N,N-Disubstituted α-aminonitriles undergo Bruylants reaction under Barbier and Reformatsky conditions with activated halides, in the presence of zinc and 10 mol% HOAc. The high yields and the simple operational conditions make this reaction an appealing, approach to N,N-disubstituted homoallylamines and β-aminoesters.

Synthesis of β-Amino Esters Using the Reformatsky Reaction with α-Amino Nitriles

The chemical behavior of α-amino nitriles towards the Reformatsky reagent has been studied.Under certain conditions, secondary aliphatic α-amino nitrile derivatives yielded a mixture of four products consisting of a β-amino ester, a β-lactam, a bulky tert

Tandem SN2-Michael Reactions for the Preparation of Simple Five- and Six-Membered-Ring Nitrogen and Sulfur Heterocycles

A one-pot tandem SN2-Michael addition sequence has been developed for the preparation of five-membered- and six-membered-ring nitrogen and sulfur heterocycles from 6- or 7-halo-2-alkenoate esters.Nitrogen-containing rings are prepared by reaction of the ω-halo-2-alkenoate ester with a primary amine in the presence of triethylamine.The sulfur analogues are generated by thiourea displacement of the halide followed by base hydrolysis of the isothiouronium salt.Yields are routinely in the 60-80percent range.Experiments are described which elucidate the chronology of the reaction sequences.Ring size and steric hindrance to the initial substitution reaction appear to be the only limitations of the procedure.

A NOVEL OXIDATIVE RING-OPENING REACTION OF ISOXAZOLIDINES: SYNTHESES OF β-AMINO KETONES AND β-AMINO ACID ESTERS FROM SECONDARY AMINES

A novel oxidative ring-opening reaction of isoxazolidines upon treatment with an electrophile and subsequently with a base gives β-amino ketones and β-amino acid esters highly efficiently.