19853-79-3

Basic information

• Product Name: 2,4-dichloro-m-toluidine
• Synonyms: 2,4-dichloro-m-toluidine;(2,4-dichloro-3-methylphenyl)amine hydrochloride;Benzenamine, 2,4-dichloro-3-methyl-;Einecs 243-371-6;(2,4-dichloro-3-methylphenyl)amine(SALTDATA: HCl);2,4-Dichloro-3-Methyl-phenylaMine;2,4-dichloro-3-methylaniline hydrochloride
• CAS NO: 19853-79-3
• Molecular Formula: C₇H₇Cl₂N
• Molecular Weight: 176.04318
• EINECS: 243-371-6
• Mol File: 19853-79-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 258.9 °C at 760 mmHg
• Flash Point: 110.4 °C
• Appearance: /
• Density: 1.334 g/cm³
• Vapor Pressure: 0.0133mmHg at 25°C
• Refractive Index: 1.599
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 2.14±0.10(Predicted)
• CAS DataBase Reference: 2,4-dichloro-m-toluidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-dichloro-m-toluidine(19853-79-3)
• EPA Substance Registry System: 2,4-dichloro-m-toluidine(19853-79-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• HazardClass: IRRITANT
• Hazardous Substances Data: 19853-79-3(Hazardous Substances Data)

Usage

General Description

2,4-dichloro-m-toluidine is a chemical compound with the molecular formula C7H8Cl2N. It is a derivative of toluidine, which is commonly used in the manufacturing of dyes, pharmaceuticals, and agricultural chemicals. 2,4-dichloro-m-toluidine itself is primarily used as an intermediate in the synthesis of agricultural chemicals, particularly herbicides. It is known to have toxic and irritating properties and should be handled with caution. In addition to its industrial uses, 2,4-dichloro-m-toluidine has been studied for its potential health and environmental effects, with researchers focusing on its potential as an endocrine disruptor and its impact on aquatic organisms.

InChI:InChI=1/C7H7Cl2N/c1-4-5(8)2-3-6(10)7(4)9/h2-3H,10H2,1H3

Upstream product

• 29682-46-0 2,6-dichloro-3-nitrotoluene 
• 118-69-4 2,6-dichlorotoluene 
• 56961-87-6 N-(2-chloro-3-methylphenyl)acetamide 
• 7647-01-0 hydrogenchloride 
• 109101-04-4 benzenesulfonic acid-(2,4-dichloro-3-methyl-anilide) 
• 19853-80-6 acetic acid-(2,4-dichloro-3-methyl-anilide) 
• 56961-88-7 N-(4-chloro-3-methylphenyl)acetamide 

Downstream Products

• 190722-79-3 2,6-dichloro-3-iodotoluene 
• 1257599-71-5 C₁₄H₁₃Cl₂N₃O 
• 500881-08-3 2,3,6-trichloro-5-nitro-toluene 
• 115423-97-7 2,3,6-trichloro-4,5-dinitro-toluene 
• 50-31-7 2,3,6-TBA 
• 190722-81-7 Acetic acid 2,6-dichloro-3-heptadecafluorooctyl-benzyl ester 
• 190722-70-4 2,6-Dichloro-3-heptadecafluorooctyl-benzaldehyde 
• 190722-82-8 (2,6-Dichloro-3-heptadecafluorooctyl-phenyl)-methanol 
• 190722-80-6 1,3-Dichloro-4-heptadecafluorooctyl-2-methyl-benzene 
• 2077-46-5 1,2,4-trichloro-3-methylbenzene 

Relevant articles and documents

Highly selective hydrogenation of aromatic chloronitro compounds to aromatic chloroamines with ionic-liquid-like copolymer stabilized platinum nanocatalysts in ionic liquids

Platinum nanoparticles (PtNPs stabilized by an ionic-liquid-like-copolymer (IP) immobilized in various ionic liquids (ILs)) effectively catalyze the selective hydrogenation of aromatic chloronitro compounds to aromatic chloroamines, a reaction of considerable commercial significance. The preparation of 2,4-dichloro-3-aminophenol (DAP) has been primarily studied due to its important industrial applications. DAP is usually prepared from 2,4-dichloro-3-nitrophenol (DNP) by reduction with hydrogen using Ni- or Pt-based catalysts. Compared to reactions in molecular (organic) solvents, the ILs system provides superior selectivity with functionalized ILs containing an alcohol group demonstrating the best recyclability, and ultimately achieving a turnover number of 2025 which is 750 fold higher than Raney nickel catalyst. A universal catalyst-ionic liquid system for the conversion of aromatic chloronitro compounds to aromatic chloroamines was also established. TEM, XPS, IR spectroscopy were used to characterize the morphology of the nanocatalysts allowing their structure to be correlated to their activity.

2-AMINOCARBONYL-QUINOLINE COMPOUNDS AS PLATELET ADENOSINE DIPHOSPHATE RECEPTOR ANTAGONISTS

Compounds of formula (I), where m, n, R1, R2, R3, R4 and R6 are described herein, are useful as inhibitors of platelet adenosine diphosphate. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compounds are also described herein.

IMIDAZO [1,2-A] PYRIDINES AND THEIR PHARMACEUTICAL USE

The invention relates to novel bradykinin antagonists of the formula: STR1 wherein R 1 is halogen,R 2 and R 3 are each hydrogen, lower alkyl, halo(lower)alkyl or acyl,R 4 is aryl having suitable substituent(s), or a heterocyclic group optionally having suitable substituent(s),Q is O or N--R 11, in which R 11 is hydrogen or acyl, andA is lower alkylene,and pharmaceutically acceptable salts thereof.