56961-87-6

Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-3-Methylacetanilide is used as an analgesic and anti-inflammatory agent for the treatment of conditions such as arthritis, menstrual cramps, and migraines. Its effectiveness in managing pain and inflammation stems from its ability to inhibit the production of prostaglandins, which are chemicals that contribute to these symptoms.
Used in Pain Management:
In the field of pain management, 2-Chloro-3-Methylacetanilide serves as a potent pain reliever, addressing acute and chronic pain conditions by reducing inflammation and the associated discomfort.
Used in Inflammation Reduction:
For inflammation reduction, 2-Chloro-3-Methylacetanilide is utilized to diminish the swelling and redness associated with various inflammatory conditions, providing relief and improving the quality of life for affected individuals.
Available in various forms such as tablets, capsules, and topical gels, 2-Chloro-3-Methylacetanilide offers flexibility in administration routes to cater to different patient needs and preferences. However, it is important to note that while generally considered safe and effective, it can cause side effects like stomach pain, heartburn, and dizziness. Therefore, it should be used with caution, particularly by individuals with a history of stomach ulcers or bleeding disorders.

Upstream product

• 7647-01-0 hydrogenchloride 
• 537-92-8 3-Methylacetanilide 
• 64-19-7 acetic acid 
• 29027-17-6 2-chloro-3-methylaniline 
• 108-24-7 acetic anhydride 

Downstream Products

• 101870-46-6 3-(acetylamino)-4-chlorobenzoic acid 
• 19853-80-6 acetic acid-(2,4-dichloro-3-methyl-anilide) 
• 249289-91-6 3-acetylamino-2-chloro-benzoic acid 
• 143360-06-9 C₉H₉BrClNO 
• 573767-71-2 4-amino-3-chloro-2-methylbenzonitrile 
• 500881-08-3 2,3,6-trichloro-5-nitro-toluene 
• 115423-97-7 2,3,6-trichloro-4,5-dinitro-toluene 
• 19853-79-3 2,4-dichloro-3-methylaniline 
• 2077-46-5 1,2,4-trichloro-3-methylbenzene 
• 50-31-7 2,3,6-TBA 
• 70383-10-7 N-(2-chloro-3-methylphenyl)-N-methylacetanilide 

Relevant academic research and scientific papers

Acylation of Phenols, Alcohols, Thiols, Amines and Aldehydes Using Sulfonic Acid Functionalized Hyper-Cross-Linked Poly(2-naphthol) as a Solid Acid Catalyst

Abstract: The hyper-cross-linked porous poly(2-naphthol) fabricated by the Friedel–Crafts alkylation of 2-naphthol has been functionalized with sulfonic acid to obtain a solid acid catalyst. The catalyst is applied for the protection of phenol, alcohols, thiols, amines and aldehydes with acetic anhydride at room temperature. The catalytic protection using the new solid acid is featured by achieving high yield at neat condition, needing no aqueous work-up and/or chromatographic separation, and showing excellent recycling efficiency, suggesting the potential of this sulfonated porous polymers as a new protection protocol in a wide range of sustainable chemical reactions. Graphical Abstract: [Figure not available: see fulltext.].

Tandem optimization of target activity and elimination of mutagenic potential in a potent series of N-aryl bicyclic hydantoin-based selective androgen receptor modulators

Pharmacokinetic studies in cynomolgus monkeys with a novel prototype selective androgen receptor modulator revealed trace amounts of an aniline fragment released through hydrolytic metabolism. This aniline fragment was determined to be mutagenic in an Ames assay. Subsequent concurrent optimization for target activity and avoidance of mutagenicity led to the identification of a pharmacologically superior clinical candidate without mutagenic potential.

Photoinduced Cyclizations of Mono- and Dianions of N-Acyl-o-chloroanilines and N-Acyl-o-chlorobenzylamines as General Methods for the Synthesis of Oxindoles and 1,4-Dihydro-3(2H)-isoquinolinones

Formation of the monoanions of a series of N-acyl-N-alkyl-o-chloroanilines by means of LDA in THF followed by irradiation with near-UV light affords 1,3-dialkyloxindoles in good yields.Similar photoinduced cyclizations of dianions derived from N-acyl-o-chloroanilines leads to 3-alkyloxindoles.Photocyclizations of mono- and dianion prepared from α,β-unsaturated o-haloanilides proceed to form 3-alkylideneoxindoles.Carbanions derived from N-acyl-o-chlorobenzylamines also undergo photoassisted ring closure to afford 1,4-dihydro-3(2H)-isoquinolinones.The influence of near-UV light and the effect of inhibitors implicate a radical-chain mechanism as the major reaction pathway in this convenient new method for oxindole and isoquinolinone synthesis.