198561-33-0

Upstream product

• 104-53-0 3-phenyl-propionaldehyde 
• 38046-39-8 cyanomethylzinc bromide 
• 1161512-43-1 (R)-5-phenethyl-2-isoxazoline 
• 851372-04-8 (2R)-2-hydroxy-4-phenylbutyl 4-methylbenzenesulfonate 
• 1410787-80-2 C₁₂H₁₃NO₃ 
• 157732-87-1 (4S)-2,2-dimethyl-4-(2-phenylethyl)-1,3-dioxolane 
• 143615-31-0 (2R)-4-phenylbutane-1,2-diol 
• 152203-65-1 (4S)-2,2-dimethyl-4-styryl-1,3-dioxolane 
• 124988-64-3 (S)-4-phenyl-1,2-butanediol 
• 1449-46-3 benzyltriphenylphosphonium bromide 
• 151-50-8 potassium cyanide 
• 125103-93-7 (+/-)-3-<(phenylthio)acetoxy>-5-phenylpentanenitrile 

Downstream Products

• 862464-35-5 (R)-6-phenethyldihydropyran-2,4-dione 
• 1260909-45-2 (3R)-3-{[(tert-butyl)(diphenyl)silyl]oxy}-5-phenylpentanenitrile 
• 862464-34-4 methyl (5R)-5-hydroxy-3-oxo-7-phenylheptanoate 

Relevant academic research and scientific papers

Organocatalysed synthesis of isoxazolines initiated by a chemoselective oxa-Michael reaction of N-BocNHOH

An organocatalysed and chemoselective one-pot oxa-Michael-cyclocondensation reaction of N-BocNHOH to unsaturated α-ketoesters is reported which affords an original entry to enantioenriched 3-isoxazoline carboxylate derivatives as biorelevant heterocyclic

Total synthesis of a mevinic acid analog

Total synthesis of mevinic acid analog 1 has been achieved efficiently starting from chiral 2,3-O-isopropylidene-D-glyceraldehyde (2). The synthesis involves Mitsunobu reaction and Evans' intramolecular oxa-Michael syn-addition reactions as key steps. Cop

Base-catalyzed isomerization of 2-isoxazolines enables a two-step enantioselective synthesis of β-hydroxynitriles from enals

The asymmetric synthesis of β-hydroxynitriles remains a challenge in organic synthesis. Herein we report a convenient synthesis of β-hydroxynitriles from enantiomerically enriched 3-unsubstituted 2-isoxazolines via a base-catalyzed ring-opening reaction that takes place without loss of enantiopurity. In combination with organocatalytic enantioselective synthesis of 3-unsubstituted 2-isoxazolines, the ring-opening enables a short 2-step synthesis of β-hydroxynitriles from α,β-unsaturated aldehydes in high enantiomeric purity.

A total synthesis of (+)- and (-)-dihydrokavain with a sonochemical blaise reaction as the key step

Starting from 2,3-O-isopropylidene-D-glyceraldehyde (2) as chiral material, the naturally occurring (S)-(+)-dihydrokavain (1a) was synthesized by a procedure that involves a sonochemical Blaise reaction as the key step. The absolute configuration of (S)-(

Method of manufacturing cyano compounds

A method of manufacturing a cyano compound by reacting a carbonyl compound with a nitrile compound having at least one α-hydrogen atom in the presence of a ligand and a metal compound of formula (III), [in-line-formulae]MX??(III) [/in-line-formulae] where

Highly Enantioselective Synthesis of β-Hydroxy Nitriles by the Cyanomethylation of Aldehydes using DPMPM as a Chiral Catalyst or Ligand

Optically active β-hydroxy nitriles in up to 93percent e.e. were obtained by the enantioselective addition of cyanomethylzinc bromide to aldehydes using DPMPM as a chiral catalyst or ligand.

Enhanced Enantioselectivity of an Enzymatic Reaction by the Sulfur Functional Group. A Simple Preparation of Optically Active β-Hydroxy Nitriles Using a Lipase

The enantioselectivity of a lipase-catalyzed hydrolysis was improved by varying the acyl residue into the sulfur functional one, i.e. the β-(phenylthio)- or β-(methylthio)acetoxy group, from acetate or valerate to realize satisfactory resolution of β-hydr

Stereorecognition Enhancement by the Sulfur Functional Group in the Lipase Hydrolysis. An Efficient Synthesis of the Optically Active β-Hydroxy Nitriles

β-phenylthio and β-methylthioacetoxy nitriles have been found to be good substrates for the kinetic resolution by lipase to give optically active β-hydroxy nitriles with high enantioselectivity.