862464-35-5

Upstream product

• 100-39-0 benzyl bromide 
• 118133-67-8 (-)-(R)-methyl 3-hydroxy-5-phenylpentanoate 
• 124988-64-3 (S)-4-phenyl-1,2-butanediol 
• 157732-87-1 (4S)-2,2-dimethyl-4-(2-phenylethyl)-1,3-dioxolane 
• 851372-04-8 (2R)-2-hydroxy-4-phenylbutyl 4-methylbenzenesulfonate 
• 143615-31-0 (2R)-4-phenylbutane-1,2-diol 
• 198561-33-0 (3R)-3-hydroxy-5-phenylpentanenitrile 
• 1449-46-3 benzyltriphenylphosphonium bromide 
• 129880-16-6 3-hydroxy-5-phenyl-pentanoic acid methyl ester 
• 30414-58-5 methyl 3-oxo-5-phenylpentanoate 
• 918148-51-3 t-butyl (R)-5-hydroxy-3-oxo-7-phenylheptanoate 

Relevant academic research and scientific papers

Chemoenzymatic synthesis of enantiomerically enriched kavalactones

Lipase-mediated kinetic resolution of methyl-3-hydroxy-5-phenylpentanoate and (6E)-ethyl 5-hydroxy-3-oxo-7-phenylhept-6-enoate is described in high enantiomeric excess and good yields. The effect of different lipases in different solvents has been screened using different acylating agents. This protocol has been extended for the preparation of enantiomerically pure biologically important kavalactones.

A total synthesis of (+)- and (-)-dihydrokavain with a sonochemical blaise reaction as the key step

Starting from 2,3-O-isopropylidene-D-glyceraldehyde (2) as chiral material, the naturally occurring (S)-(+)-dihydrokavain (1a) was synthesized by a procedure that involves a sonochemical Blaise reaction as the key step. The absolute configuration of (S)-(