851372-04-8

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 143615-31-0 (2R)-4-phenylbutane-1,2-diol 
• 1449-46-3 benzyltriphenylphosphonium bromide 
• 768-56-9 4-Phenylbut-1-ene 
• 124988-64-3 (S)-4-phenyl-1,2-butanediol 
• 152203-65-1 (4S)-2,2-dimethyl-4-styryl-1,3-dioxolane 
• 157732-87-1 (4S)-2,2-dimethyl-4-(2-phenylethyl)-1,3-dioxolane 

Downstream Products

• 862464-35-5 (R)-6-phenethyldihydropyran-2,4-dione 
• 862464-34-4 methyl (5R)-5-hydroxy-3-oxo-7-phenylheptanoate 
• 198561-33-0 (3R)-3-hydroxy-5-phenylpentanenitrile 
• 1053608-70-0 (3R,4R,5S)-4-Acetylamino-5-azido-3-((S)-1-ethyl-3-phenyl-propoxy)-cyclohex-1-enecarboxylic acid ethyl ester 
• 71747-37-0 (S)-1-phenylpentan-3-ol 
• 141036-66-0 (R)-(2-phenylethyl)oxirane 

Relevant academic research and scientific papers

Total synthesis of a mevinic acid analog

Total synthesis of mevinic acid analog 1 has been achieved efficiently starting from chiral 2,3-O-isopropylidene-D-glyceraldehyde (2). The synthesis involves Mitsunobu reaction and Evans' intramolecular oxa-Michael syn-addition reactions as key steps. Cop

PROCESS FOR PREPARATION OF 13,14-DIHYDRO-PGF2α DERIVATIVES

Invention relates to the process for preparation of 13,14-dihydro-PGF2α derivatives of R or S configuration at carbon atom in omega chain substituted by hydroxyl, represented by formula (I), wherein the meaning of substituents is defined in the description. Compounds (I) are valuable biologically active substances or intermediates thereof. The invention especially relates to the process for preparation of 13,14-dihydro-15(R)-17-substituted-18,19,20-trinor-PGF2α, ie. latanoprost.

A total synthesis of (+)- and (-)-dihydrokavain with a sonochemical blaise reaction as the key step

Starting from 2,3-O-isopropylidene-D-glyceraldehyde (2) as chiral material, the naturally occurring (S)-(+)-dihydrokavain (1a) was synthesized by a procedure that involves a sonochemical Blaise reaction as the key step. The absolute configuration of (S)-(

Highly stereoselective Friedel-Crafts alkylations of unactivated benzenes by episulfonium ion cyclizations

Intermolecular additions of highly enantiomerically enriched episulfonium ions onto activated benzene rings are known to accomplish chiral Friedel-Crafts alkylations. Unactivated benzenes are either unreactive or can give low stereoselectivities. Intramol