19901-87-2

Basic information

• Product Name: 1-aMino-1-phenylpropan-2-ol
• Synonyms: 1-aMino-1-phenylpropan-2-ol
• CAS NO: 19901-87-2
• Molecular Formula: C₉H₁₃NO
• Molecular Weight: 151.20562
• Mol File: 19901-87-2.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-aMino-1-phenylpropan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-aMino-1-phenylpropan-2-ol(19901-87-2)
• EPA Substance Registry System: 1-aMino-1-phenylpropan-2-ol(19901-87-2)

Safety Data

• Hazardous Substances Data: 19901-87-2(Hazardous Substances Data)

Usage

General Description

1-Amino-1-phenylpropan-2-ol, also known as cathinone or beta-hydroxyamphetamine, is a psychoactive and stimulant drug that belongs to the phenethylamine class of compounds. It is a chiral molecule, meaning it has two enantiomers, d-cathinone and l-cathinone, with the l-form being the naturally-occurring and biologically-active isomer. Cathinone is predominantly found in the khat plant, which is native to the Horn of Africa and the Arabian Peninsula, and has been traditionally consumed for its stimulant effects. Chemically, cathinone is structurally similar to amphetamine, and it primarily functions as a releasing agent of norepinephrine and dopamine in the brain. Due to its psychoactive properties, cathinone has been a subject of growing concern as a recreational drug, with its misuse linked to harmful side effects such as tachycardia, hypertension, and addiction. As a result, cathinone and its analogs are classified as controlled substances in many jurisdictions, and their production, distribution, and possession are regulated.

Upstream product

• 25355-34-4 1-phenyl-propane-1,2-dione 1-oxime 
• 91791-27-4 (+/-)-(Z)-2-hydroxy-1-phenyl-1-propanone oxime 
• 91791-26-3 (+/-)-(E)-2-hydroxy-1-phenyl-1-propanone oxime 
• 103-79-7 1-phenyl-acetone 
• 90917-82-1 5-methyl-4-phenyl-4,5-dihydro-oxazol-2-ylamine 
• 122898-35-5 C₁₆H₁₇NO₃ 
• 127209-38-5 1-Dimethylsilanyl-2,2,3-trimethyl-4-phenyl-[1,2]azasiletidine 
• 622-42-4 1-nitro-1-phenylmethane 
• 75-07-0 acetaldehyde 
• 4541-87-1 cis-1-phenylpropene oxide 
• 766-90-5 cis-1-phenyl-1-propylene 
• 88784-94-5 4-nitro-benzoic acid-((1RS,2SR)-2-hydroxy-1-phenyl-propylamide) 
• 19901-87-2 threo-amino-1-phenyl-1-propanol-2 
• 122898-35-5 C₁₆H₁₇NO₃ 

Downstream Products

• 88784-94-5 4-nitro-benzoic acid-((1RS,2SR)-2-hydroxy-1-phenyl-propylamide) 
• 19901-87-2 (1R,2S/1R,2R)-1-amino-1-phenylpropan-2-ol 
• 88784-94-5 4-nitro-benzoic acid-((1RS,2RS)-2-hydroxy-1-phenyl-propylamide) 
• 127744-61-0 (1S,2R)-1-Phenyl-2-{[1-thiophen-2-yl-meth-(E)-ylidene]-amino}-propan-1-ol 
• 2165-67-5 (1RS,2SR)-1-amino-1-cyclohexyl-propan-2-ol 
• 88122-90-1 (+/-)-5c-methyl-2,4r-diphenyl-4,5-dihydro-oxazole 

Relevant articles and documents

Regio- and stereoselective multi-enzymatic aminohydroxylation of β-methylstyrene using dioxygen, ammonia and formate

We report an enzymatic route for the formal regio- and stereoselective aminohydroxylation of β-methylstyrene that consumes only dioxygen, ammonia and formate; carbonate is the by-product. The biocascade entails highly selective epoxidation, hydrolysis and hydrogen-borrowing alcohol amination. Thus, β-methylstyrene was converted into 1R,2R and 1S,2R-phenylpropanolamine in 59-63% isolated yields, and up to >99.5 : 0.5 dr and er.

Platinum-Catalyzed Intramolecular Hydrosilation of Allylamines: Formation of 1-Aza-2-silacyclobutanes and Application to Stereoselective Synthesis of 2-Amino Alcohols

N,N-Bis(dimethylsilyl)allylamines undergo intramolecular hydrosilation in the presence of Pt2O>2 (0.2 mol percent) to form four-membered cyclic compounds, 1-aza-2-silacyclobutane derivatives, which can be transformed into 2-amino alcohols by oxidation with 30percent H2O2 in the presence of KF and KHCO3.

STEREOSELECTIVE CATALYTIC HYDROGENERATION OF alpha -HYDROXY KETOXIMES.

Two isomers (E and Z) of benzoin oxime and 2-hydroxy-1-phenyl-1-propanone oxime were catalytically hydrogenated by using palladium on charcoal and erythro amino alcohols were obtained in about 80% diastereomeric excess. The syn-anti isomerization of these oximes in the presence of palladium on charcoal was also studied in connection with the stereoselectivity of the catalytic hydrogenation of the oximes.