1-[2'-(trimethylsilyl)ethoxymethyl]-2-phenylsulfonylimidazole: A new reagent for the preparation of C-4 substituted imidazoles

Article abstract of DOI:10.1016/S0040-4039(97)10128-9

The title compound provides for the efficient C-4 metallation of the imidazole nucleus. Further reactions lead to trisubstituted imidazoles which can be selectively deprotected at the N₁ and C₂ positions under mild conditions to maximize the potential for further elaboration.