1992-48-9

Basic information

• Product Name: TETRAISOPROPYL ORTHOSILICATE
• Synonyms: TETRAKIS(ISOPROPOXY)SILANE;TETRAISOPROPOXYSILANE;TETRAISOPROPYLSILANE;Tetraisopropylsilane(Tetraisopropyl orthosilicate);TETRAISOPROPYL ORTHOSILICATE;SILICON TETRA-I-PROPOXIDE;tetrakis(1-methylethyl) orthosilicate;Tetraisopropylorthosilate
• CAS NO: 1992-48-9
• Molecular Formula: C₁₂H₂₈O₄Si
• Molecular Weight: 264.43
• EINECS: 217-875-1
• Product Categories: Si (Classes of Silicon Compounds);Si-O Compounds;Tetraalkoxysilanes;Crosslinkers;Crosslinking Agents;Orthosilicate
• Mol File: 1992-48-9.mol
• Article Data: 8

Chemical Properties

• Melting Point: <0°C
• Boiling Point: 185 °C
• Flash Point: 76°C
• Appearance: Colorless transparent liquid
• Density: 0.88
• Vapor Pressure: 0.113mmHg at 25°C
• Refractive Index: 1.3895
• CAS DataBase Reference: TETRAISOPROPYL ORTHOSILICATE(CAS DataBase Reference)
• NIST Chemistry Reference: TETRAISOPROPYL ORTHOSILICATE(1992-48-9)
• EPA Substance Registry System: TETRAISOPROPYL ORTHOSILICATE(1992-48-9)

Safety Data

• Statements: 20-36/37/38
• Safety Statements: 26-36/37/39
• RIDADR: 1993
• TSCA: No
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 1992-48-9(Hazardous Substances Data)

Usage

Applications

Tetraisopropoxysilane, the iso-propyl ester of orthosilicic acid, is a colorless clear liquid. It has the following application: As an inorganic binder for refactory fillers and pigments, like precision investment castings. As a second backup casting coating. It cures faster than silica system. May be hydrolyzed to form silicon dioxide (silica). As a binder in zinc-rich (corrosion resistant) coating. As a starting material for sol-gel process. As a crosslinking agent for silicone sealant. As a drying agent in sealing compositions. As a chemical intermediate.

Chemical Properties

Colorless transparent liquid

Uses

it is impurity of Calcitonin . Calcitonin (salmon) (C144555), is a 32-amino acid linear polypeptide hormone that is produced in thyroid in humans. It acts to reduce blood calcium (Ca2+), opposing the effects of parathyroid hormone (PTH).

InChI:InChI=1/C12H28O4Si/c1-9(2)13-17(14-10(3)4,15-11(5)6)16-12(7)8/h9-12H,1-8H3

Upstream product

• 541-42-4 i-propyl nitrite 
• 681-84-5 tetramethylorthosilicate 
• 67-63-0 isopropyl alcohol 
• 18145-76-1 dichlorodiisopropoxysilane 
• 16066-04-9 disilicic(III)-oic acid hexaisopropyl ester 
• 513-81-5 2,3-dimethyl-buta-1,3-diene 
• 75-85-4 tert-Amyl alcohol 
• 12078-28-3 dicarbonylcyclopentadienyliodoiron(II) 
• 10026-04-7 tetrachlorosilane 
• 22831-39-6 magnesium silicide 
• 546-68-9 titanium(IV) isopropylate 
• 101519-13-5 dipotassium tris(1,2-benzenediolato-O,O′)silicate 
• 919-36-8 tri-isopropoxysilanethiol 
• 17898-38-3 triisopropoxychlorosilane 

Downstream Products

• 1992-37-6 Triisopropyloxy-(2-isopropyloxycarbonyl-benzoyloxy)-silicon 
• 1992-36-5 Diisopropyloxy-bis-(2-isopropyloxycarbonyl-benzoyloxy)-silicon 
• 112926-00-8 silica gel 
• 17903-04-7 (Oi-pr)3Si(Oph) 
• 18057-21-1 (Oi-pr)2Si(Oph)2 
• 18740-82-4 (Oi-pr)Si(Oph)3 
• 1623-24-1 isopropylphosphoric acid 
• 1611-31-0 diisopropylphosphate 
• 513-02-0 triisopropyl phosphate 
• 38753-50-3 1-isopropoxy-2-nitrobenzene 
• 51963-59-8 isopropyl hypophosphite 
• 13336-50-0 isopropyl phenylphosphinate 
• 107-44-8 O-isopropyl methylphosphonofluoridate 
• 638-11-9 isopropyl butyrate 

Relevant articles and documents

Pentacoordinate dihydridosilicates: Synthesis, structure, and aspects of their reactivity

The reactions of H- with trialkoxysilanes provide a unique and facile entry to anionic pentacoordinate dihydridosilicates [H2Si(OR)3]-, isolated as stable crystalline products in the case of bulky R groups (R = i-Pr, s-Bu, c-C6H11). Their dynamic behavior (R = i-Pr and s-Bu) has been investigated by 29Si and variable-temperature 1H NMR. Intramolecular exchange of H atoms between axial and equatorial sites is indicated and was found to be significantly dependant on the nature of the solvent. Compared to HSi(OR)3, K[H2Si(OR)3] are versatile reagents: (1) the silicon atom is an electrophilic center and this leads to nucleophilic displacements of the alkoxy groups with Grignard reagents and organolithiums; (2) they are able to reduce very easily carbonyl derivatives to alcohols without any catalyst; (3) they react with primary halides through an ionic mechanism leading to the alkane; (4) the reaction with benzylic halides is more complex and affords the dimer as the major product, the formation of which can be explained by a SET process; (5) the ability to donate one electron is confirmed in the reaction with Cp(CO)2FeI and by direct ESR observation of stable radical intermediates.

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Reaction of silicon with alcohols in autoclave

A reaction of activated silicon with alcohols in an autoclave at 240—270 °C was studied. It was found that primary alcohols form tetraalkoxysilanes Si(OR)4 with high selectivity (up to 97%), while the secondary PriOH gave a mixture of compounds HSi(OPri)3, Si(OPri)4, HSi(OPri)2OSi(OPri)2H, HSi(OPri)2OSi(OPri)3, and Si(OPri)3OSi(OPri)3 with the predominance of trialkoxysilane (up to 67%). Carrying out the reaction under the indicated conditions has the advantage of experimental simplicity, reagent availability, high conversion of silicon, good isolated yields of products.

PRECURSORS FOR SILICA OR METAL SILICATE FILMS

A composition selected from the group consisting of bis(tert-butoxy)(isopropoxy)silanol, bis(isopropoxy)(tert-butoxy)silanol, bis(tert-pentoxy)(isopropoxy)silanol, bis(isopropoxy)(tert-pentoxy)silanol, bis(tert-pentoxy)(tert-butoxy)silanol, bis(tert-butoxy)(tert-pentoxy)silanol and mixtures thereof; its use to form a metal or metalloid silicate layer on a substrate and the synthesis of the mixed alkoxysilanols.