199292-64-3

Upstream product

• 67-56-1 methanol 
• 125455-89-2 3-(2-vinyl-4,5-dimethoxyphenyl)-6,7-dimethoxy-2-methyl-1,2-dihydroisoquinoline-1-one 
• 60315-12-0 3-(2-vinyl-4,5-dimethoxyphenyl)-6,7-dimethoxy-1,2-dihydroisoquinol-1-one 
• 470461-20-2 [(Z)-2-(3,4-Dimethoxy-phenyl)-1-(4,5-dimethoxy-2-vinyl-phenyl)-vinyl]-methyl-carbamic acid ethyl ester 
• 470461-18-8 (Z)-ethyl 1-(4,5-dimethoxy-2-vinylphenyl)-2-(3,4-dimethoxyphenyl)vinylcarbamate 
• 22185-86-0 ethyl 1-(3',4'-dimethoxybenzylidene)-3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinecarboxylate 

Downstream Products

• 114253-63-3 O-methyl-6-oxofagaronine 

Relevant academic research and scientific papers

A new route to 3-(2-vinylphenyl)-2-methyl-2H-isoquinolin-1-ones and benzo[c]phenanthridines: Total synthesis of fagaronine

Treatment of N-carbethoxy-1-benzylideneisoquinolines with LDA gives N-ethoxycarbonyl-1-amino-1-(2-vinylphenyl)-2-phenylethylenes, which can be transformed into 3-(2-vinylphenyl)-2-methyl-2H-isoquinolin-1-ones by Bischler-Napieralski reactions, and thence

Applications of a novel carbon-nitrogen bond cleavage reaction: Part IV - A new biomimetic synthesis of benzo[c]phenanthridine alkaloids

A highly practical synthesis of benzo[c]phenanthridine alkaloids nitidine and 2-methoxyfagaronine has been developed from the corresponding protoberberines. The 8-oxoprotoberberines 1-3 on reaction with NaH and DMF give the C-N bond cleavage intermediates