199393-31-2

Upstream product

• 4248-19-5 tert-butyl carbazate 
• 36438-64-9 p-benzyloxystyrene 
• 4397-53-9 p-benzyloxybenzaldehyde 
• 100-39-0 benzyl bromide 
• 127526-64-1 (R)-(4-benzyloxyphenyl)(tert-butoxycarbonylamino)acetic acid 
• 69489-40-3 D-2-[p-(benzyloxy)phenyl]glycine 
• 22818-40-2 D-4-hydroxyphenylglycine 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 289051-79-2 (R)-2-hyrdoxy-1-(4-benzyloxyphenyl)ethylamine 
• 468732-53-8 2,2'-(1-ethylpropylidene)bis[(4R)-4-(4-benzyloxy)phenyl-4,5-dihydro-1,3-oxazole] 
• 600738-29-2 N₁,N₃-di{(1R)-1-[4-(benzyloxy)phenyl]-2-chloroethyl}-2,2-diethylmanonamide 
• 600738-27-0 N₁,N₃-di{(1R)-1-[4-(benzyloxy)phenyl]-2-hydroxyethyl}-2,2-diethylmanonamide 
• 342898-57-1 (R)-N-(tert-butoxycarbonyl)-2-(5-benzyloxy-2-bromophenoxy)-1-(4-benzyloxyphenyl)ethylamine 
• 691889-35-7 (R)-N-(t-butoxycarbonyl)-4-(t-butyldimethylsiloxy)phenylglycinol 
• 1286280-72-5 tert-butyl (1R)-2-hydroxy-1-[4-(2-methylpentyloxy)phenyl]ethylcarbamate 
• 1286280-51-0 {(R)-2-hydroxy-1-[4-((S)-2-methyl-butoxy)phenyl]ethyl}carbamic acid t-butyl ester 
• 1286280-78-1 tert-butyl (R)-2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-1-(4-((S)-2-methylbutoxy)phenyl)ethylcarbamate 
• 1286280-73-6 (2R)-2-amino-2-[4-(2-methylpentyloxy)phenyl]ethanol hydrochloride 
• 1286280-79-2 (1S,2S)-2-thiophen-2-yl-cyclopropanecarboxylic acid {(R)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-1-[4-((S)-2-methyl-butoxy)phenyl]ethyl}amide 
• 1286280-41-8 (1S,2S)-2-thiophen-2-yl-cyclopropanecarboxylic acid {(R)-2-hydroxy-1-[4-(2-methyl-pentyloxy)phenyl]ethyl}amide 
• 1286280-43-0 (1S,2S)-2-thiophen-2-yl-cyclopropanecarboxylic acid {(R)-2-amino-1-[4-((S)-2-methyl-butoxy)phenyl]ethyl}amide 
• 1286280-52-1 {(R)-2-hydroxy-1-[4-((S)-2-methyl-butoxy)phenyl]ethyl}amine hydrochloride 

Relevant academic research and scientific papers

MODULATORS OF G PROTEIN-COUPLED RECEPTOR 88

The present disclosure is generally directed to compounds which can modulate G-protein coupled receptor 88, compositions comprising such compounds, and methods for modulating G-protein coupled receptor 88.

Compounds with hydroxycarbonyl-halogenoalkyl side chain

The present invention provides a compound consisting of a moiety and a group chemically bonded to said moiety, wherein said moiety contains a compound having low activity following oral administration or its parent scaffold and said group has the followin

Syntheses of amino alcohols and chiral C2-symmetric bisoxazolines derived from O-alkylated R-4-hydroxyphenylglycine and S-tyrosine

Chiral C2-symmetric bisoxazolines 1b-f and 2b,c, derived from 4′-O-alkylated R-4-hydroxyphenylglycine or S-tyrosine, were prepared. As intermediates, a series of chiral amino alcohols possessing substituted phenolic groups was prepared and fully characterized.

From styrenes to enantiopure α-arylglycines in two steps

Direct enantioselective synthesis of (R)- and (S)-N-Cbz- or N- BOC-protected α-arylglycinols from styrenes via catalytic asymmetric aminohydroxylation, with enantioselective up to 99% and isolated yields up to 80%, is described. In a subsequent oxidation step, these glycinols yield the corresponding carbamate-protected α-arylglycines.