199522-67-3Relevant academic research and scientific papers
USE OF SOMATOSTATIN AGONISTS AND ANTAGONISTS FOR TREATING DISEASES RELATED TO THE EYE
-
, (2008/06/13)
The invention relates to the use of a somatostatin receptor ligand of nonpeptide origin, e.g. of general formula (Ia) or (Ib) or a pharmaceutically acceptable salt thereof, which has high and/or selective affinity to the somatostatin receptor protein designated SSTR4, for the preparation of a medicament for the treatment of a disease associated with an adverse condition in the retina and/or iris-ciliary body of a mammal. Such conditions being high intraocular pressure (IOP) and/or deep ocular infections. The diseases which may be treated are e.g. glaucoma, stromal keratitis, iritis, retinitis, cataract and conjunctivitis.
Constrained somatostatin agonists and antagonists
-
, (2008/06/13)
The present invention relates to a compound of general formula I for treating medical disorders related to binding to human somatostatin receptor subtypes.
Somatostatin agonists and antagonists
-
, (2008/06/13)
The present invention relates to compounds, compositions containing them, and their use for treating medical disorders related to binding to human somatostatin receptor subtypes.
Use of somatostatin agonists and antagonists for treating diseases related to the eye
-
, (2008/06/13)
The invention relates to the use of a somatostatin receptor ligand of nonpeptide origin, e.g. of the general formula Ia or Ib or a pharmaceutically acceptable salt thereof, which has high and/or selective affinity to the somatostatin receptor protein designated SSTR4 and, for the preparation of a medicament for the treatment of a disease associated with an adverse condition in the retina and/or iris-ciliary body of a mammal. Such conditions are high intraocular pressure (IOP) and/or deep ocular infections. The diseases which may be treated are e.g. glaucoma, stromal keratitis, iritis, retinitis, cataract and conjunctivitis.
Nonpeptide somatostatin agonists with sst4 selectivity: Synthesis and structure-activity relationships of thioureas
Liu, Shenquan,Tang, Cheng,Ho, Bin,Ankersen, Michael,Stidsen, Carsten E.,Crider, A. Michael
, p. 4693 - 4705 (2007/10/03)
Utilizing NNC 26-9100 (11) as a structural lead, a variety of nonpeptide derivatives of somatostatin were synthesized and evaluated for sst2 and sst4 receptor binding affinity. A novel thiourea scaffold was utilized to attach (1) a h
