199525-58-1Relevant academic research and scientific papers
A short, efficient synthesis of monofluoro ketomethylene peptide isostere core units
Hoffman, Robert V.,Saenz, James E.
, p. 8469 - 8472 (1997)
Monofluoro ketomethylene peptide isosteres can be prepared by a four step sequence from carboxylic acids in satisfactory overall yields (30-60%). Fluorine is introduced by electrophilic fluorination of a β-ketoester enolate with SelectFluor(TM).
