A short, efficient synthesis of monofluoro ketomethylene peptide isostere core units

DOI: 10.1016/S0040-4039(97)10282-9

Source and publish data:

Tetrahedron Letters p. 8469 - 8472 (1997)

Update date:2022-08-03

Topics:

Authors:

Hoffman, Robert V.

Saenz, James E.

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Article abstract of DOI:10.1016/S0040-4039(97)10282-9

Monofluoro ketomethylene peptide isosteres can be prepared by a four step sequence from carboxylic acids in satisfactory overall yields (30-60%). Fluorine is introduced by electrophilic fluorination of a β-ketoester enolate with SelectFluor(TM).

Full text of DOI:10.1016/S0040-4039(97)10282-9

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