Tetrahedron Letters p. 8469 - 8472 (1997)
Update date:2022-08-03
Topics:
Hoffman, Robert V.
Saenz, James E.
Monofluoro ketomethylene peptide isosteres can be prepared by a four step sequence from carboxylic acids in satisfactory overall yields (30-60%). Fluorine is introduced by electrophilic fluorination of a β-ketoester enolate with SelectFluor(TM).
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