19960-63-5Relevant academic research and scientific papers
Thiazole synthesis by cyclocondensation of 1-alkynyl(phenyl)- λ3-iodanes with thioureas and thioamides
Miyamoto, Kazunori,Nishi, Yoshio,Ochiai, Masahito
, p. 6896 - 6899 (2005)
(Chemical Equation Presented) The isolation and intramolecular cyclization of (S)-(1-alkynyl)isothiouronium and (S)-(1-alkynyl)thiobenzimidonium salts suggest the mechanism for the one-pot synthesis of 2,4-disubstituted thiazoles (see scheme; Ms = methanesulfonyl): Michael addition of sulfur nucleophiles to hypervalent iodanes followed by the 1,2-rearrangement of sulfenyl groups in the resulting alkylidene carbenes.
Synthesis of thiazoles and aminothiazoles from β-keto tosylates under supramolecular catalysis in the presence of β-cyclodextrin in water
Kumar, V. Pavan,Narender,Sridhar,Nageswar,Rao, K. Rama
, p. 4331 - 4336 (2008/03/13)
This is the first report on the supramolecular synthesis of thiazoles/aminothiazoles from β-keto tosylates and thioamide/thiourea in water in the presence of β-cyclodextrin in impressive yields. Formation of inclusion complexes was explained from 1H NMR studies. Copyright Taylor & Francis Group, LLC.
