199672-06-5

Basic information

• Product Name: 1-(4-FLUORO-BENZYL)-PIPERAZINE 2HCL
• Synonyms: 1-(4-FLUORO-BENZYL)-PIPERAZINE 2HCL;Piperazine, 1-[(4-fluorophenyl)Methyl]-, dihydrochloride;4-fluoro BZP (hydrochloride)
• CAS NO: 199672-06-5
• Molecular Formula: C11H15FN2.2ClH
• Molecular Weight: 0
• Mol File: 199672-06-5.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(4-FLUORO-BENZYL)-PIPERAZINE 2HCL(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-FLUORO-BENZYL)-PIPERAZINE 2HCL(199672-06-5)
• EPA Substance Registry System: 1-(4-FLUORO-BENZYL)-PIPERAZINE 2HCL(199672-06-5)

Safety Data

• Hazardous Substances Data: 199672-06-5(Hazardous Substances Data)

Usage

Description

Benzylpiperazines (BZP) are stimulant drugs which inhibit monoamine uptake. BZP and substituted derivatives, such as 1-(3,4-methylenedioxybenzyl)piperazine, have been identified as designer drugs or drugs of abuse. 4-fluoro BZP is a substituted BZP with a potential for abuse. The physiological and toxicological properties of this compound have not been evaluated. This product is intended for forensic and research applications. 4-fluoro BZP is also used as a precursor in the synthesis of certain bioactive compounds.

Upstream product

• 110-85-0 piperazine 
• 352-11-4 1-chloromethyl-4-fluorobenzene 
• 77278-77-4 4-(4-fluorobenzyl)piperazine-1-tert-butoxycarbonyl ester 
• 142-64-3 piperazine dihydrochloride 
• 6091-62-9 piperazine dihydrochloride hydrate 
• 7542-23-6 piperazine hydrochloride 

Relevant articles and documents

Simplified procedure for general synthesis of monosubstituted piperazines-from a batch reaction vessel to a flow (microwave) reactor

We reported a novel simplified synthetic procedure for the preparation of monosubstituted piperazine derivatives which can now be easily prepared in a one-pot-one-step way from a protonated piperazine with no need of introduction of a protecting group. Reactions, proceeding either at room or higher temperatures in common solvents, involve heterogeneous catalysis by metal ions supported on commercial polymeric resins. A general synthetic scheme was successfully applied to afford a wide range of monosubstituted piperazines. Furthermore, we picked up a set of piperazine derivatives and studied the possibilities of microwave acceleration of given synthetic reactions to make them even more efficient. Our research proceeded from a simple batch technique to the construction of a flow microwave reactor prototype and resulted in promising findings which are summarized and discussed in the article.

Aralkyl-alcohol peiperazine derivatives adn their uses as antidepressant

Aryl alkanol piperazine derivatives of the formula and pharmaceutical compositions comprising the same. Also disclosed are methods for treating depression using the pharmaceutical compositon. Compounds of the invention have excellent dual inhibitory actions to the uptake of the mono-amines neurotransmitter, good antidepressant activities and minor side effects.

Calcium channel blockers

The invention involves the identification of a family of compounds which block calcium channels. The compounds can be formulated in pharmaceutical carriers and administered to subjects. The compounds are useful for treating disorders associated with calci