19968-57-1Relevant academic research and scientific papers
Reigoselective arylation of thiazole derivatives at 5-position via Pd catalysis under ligand-free conditions
Liu, Xiang-Wei,Shi, Jiang-Ling,Yan, Jia-Xuan,Wei, Jiang-Bo,Peng, Kun,Dai, Le,Li, Chen-Guang,Wang, Bi-Qin,Shi, Zhang-Jie
, p. 5774 - 5777 (2013)
An efficient regioselective arylation of thiazole derivatives via Pd-catalyzed C-H activation is reported. The transformation was hypothesized through a Pd(0/II) catalytic cycle in the absence of special ligand sets. This method provided an efficient proc
A 2, 5 - diaryl five-membered heterocyclic aromatic preparation method
-
Paragraph 0033; 0034; 0035, (2019/05/15)
The invention relates to a 2, 5 - diaryl five-membered heterocyclic aromatic preparation method, the method is to turn the diaryl Iodized salt compounds, five-membered heterocyclic aromatic compound, catalyst, ligand, alkali and solvent are mixed uniformly, in 100 °C -140 °C lower sealing reaction for 24 hours, the reaction solution obtained after the reaction is complete; the reaction solution are often gauge extraction, drying, concentration, column chromatography separation to obtain the 2, 5 - diaryl five-membered heterocyclic aromatic compounds. The invention belongs to a pot of reaction of the atom economy, simple operation, high yield, can realize the large-scale production, in functional organic material, biological active compounds and pharmaceutical synthesis of better industrial application prospect.
Pd/Cu-cocatalyzed reigoselective arylation of thiazole derivatives at 2-position under ligand-free conditions
Gu, Jian,Cai, Chun
, p. 56311 - 56315 (2015/07/15)
An efficient protocol for regioselective arylation of thiazole derivatives at the 2-position via palladium- and copper-catalyzed C-H bond activation under ligand-free conditions has been developed. The reaction proceeds smoothly with 1% palladium catalyst in the presence of 20% Cu(TFA)2 to furnish the desired products. The direct C-H arylation and no ligand made this method synthetically useful for the arylation of thiazoles at the 2-position.
Convenient one-pot two-step synthesis of 1,3-thiazoles via organocatalyzed epoxidation of nitroolefins
Wei, Shengwei,Wei?, Katharina M.,Tsogoeva, Svetlana B.
supporting information, p. 3441 - 3446 (2013/01/15)
A convenient novel one-pot two-step strategy and its substrate scope for the synthesis of 1,3-thiazole heterocycles via organocatalytic epoxidation of nitroolefins with the TBHP/DBU system, and subsequent reaction of α-nitroepoxides with thioamides is reported. Georg Thieme Verlag KG · Stuttgart · New York.
Novel one-pot process for the synthesis of 1,3-thiazoles via organocatalysed epoxidation of nitro-olefins
Weiss, Katharina M.,Wei, Shengwei,Tsogoeva, Svetlana B.
experimental part, p. 3457 - 3461 (2011/06/20)
A facile one-pot two-step process for the synthesis of 1,3-thiazole heterocycles via organocatalytic epoxidation of nitro-olefins with the t-BuOOH/DBU system, and subsequent reaction of α-nitro-epoxides with thioamides under mild conditions has been devel
Decarboxylative cross-coupling of azoyl carboxylic acids with aryl halides
Zhang, Fengzhi,Greaney, Michael F.
supporting information; experimental part, p. 4745 - 4747 (2010/12/24)
Decarboxylative cross-coupling of thiazole and oxazole-5-carboxylic acids with aryl halides is reported. Under a bimetallic system of catalytic palladium and a stoichiometric silver carbonate, a variety of (hetero)arylated azoles can be prepared in excell
Facile one-pot synthesis of three different substituted thiazoles from propargylic alcohols
Gao, Xun,Pan, Ying-Ming,Lin, Min,Chen, Li,Zhan, Zhuang-Ping
supporting information; experimental part, p. 3259 - 3266 (2010/08/21)
Three different substituted thiazoles have been successfully synthesized from readily available propargylic alcohols. Various secondary propargylic alcohols or tertiary propargylic alcohols participated well in the reaction, providing the desired products in good yields. This method provides a flexible and rapid route to substituted thiazoles. The Royal Society of Chemistry 2010.
Thionation of ω-acylamino ketones with Lawesson's reagent: Convenient synthesis of 1,3-thiazoles and 4H-1,3-thiazines
Nishio, Takehiko,Ori, Mayuko
, p. 2347 - 2354 (2007/10/03)
The reaction of ω-acylamino ketones with Lawesson's reagent (=2,4-bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane 2,4-disulfide; LR) is described. Treatment of 2-acylamino ketones 1 (n = 0) with LR gave 1,3-thiazole derivatives 3 in good yields (Scheme 1
