16735-29-8

Upstream product

• 93-97-0 benzoic acid anhydride 
• 302-72-7 rac-Ala-OH 
• 21819-72-7 rac-4-benzoyl-4-methyl-2-phenyloxazol-5-one 
• 100-58-3 phenylmagnesium bromide 
• 2198-64-3 N-Benzoylalanine 
• 67948-51-0 (2-Methyl-3-phenyl-2H-azirin-2-yl)-phenyl-methanone 
• 55-21-0 benzamide 
• 93-55-0 1-phenyl-propan-1-one 
• 21819-71-6 4-methyl-2-phenyloxazol-5-yl benzoate 
• 98-88-4 benzoyl chloride 
• 51127-13-0 2-phenyl-4-methyl-4H-oxazolin-5-one 
• 71-43-2 benzene 
• 194937-41-2 N-(1-Methyl-2-oxo-2-phenyl-ethyl)-selenobenzamide 

Downstream Products

• 2549-31-7 4-methyl-2,5-diphenyloxazole 
• 117764-66-6 5-methyl-3,6-diphenyl-4,5-dihydro-[1,2,4]triazine 
• 4380-71-6 N-(2-hydroxy-1-methyl-2-phenylethyl)benzamide 
• 19968-57-1 4-methyl-2,5-diphenyl-1,3-thiazole 
• 16735-19-6 2-amino-1-phenylpropan-1-one hydrochloride 
• 4380-71-6 (1R*,2R*)-N-<(2-phenyl-2-hydroxy-1-methyl)ethyl>benzamide 

Relevant academic research and scientific papers

Generation of 1,3-selenaza-1,3-butadienes by thermal cycloreversion of 2,4,6-trisubstituted 6H-1,3,5-oxaselenazines

1,3-Selenaza-1,3-butadienes were generated by thermal cycloreversion of 6H-1,3,5-oxaselenazines, and were trapped with dienophiles or nucleophiles to give the corresponding [4+2] cycloadducts or 1,4-adducts, respectively.

Base-Induced Transformation of 2-Acyl-3-alkyl-2H-azirines to Oxazoles: Involvement of Deprotonation-Initiated Pathways

An experimental study of base-induced transformation reaction of 2-acyl-3-alkyl-2H-azirines to oxazoles indicated that a deprotonation-initiated mechanism is involved, in addition to nucleophilic addition to the imine functionality. Calculations suggested

Transition-metal-free oxidative α-C-H amination of ketones via a radical mechanism: Mild synthesis of α-amino ketones

A transition-metal-free direct α-C.H amination of ketones has been developed using commercially available ammonium iodide as the catalyst and sodium percarbonate as the co-oxidant. A wide range of ketone ((hetero)aromatic or nonaromatic ketones) and amine (primary/secondary amines, anilines, or amides) substrates undergo cross-coupling to generate synthetically useful α-amino ketones. The mechanistic studies indicated that a radical pathway might be involved in the reaction process. The utility of the method is highlighted through a concise one-step synthesis of the pharmaceutical agent amfepramone.

Flow-vacuum pyrolysis of 2,5-diphenyl-4-methyloxazole

The flow-vacuum pyrolysis of 2,5-diphenyl-4-methyloxazole (4) at 1000°C and 0.5 Torr afforded a complex reaction mixture containing: benzonitrile, diphenylmethane, 9,10-dimethylphenantrene, 9,10-dimethylantracene, fluorene, o-benzylbenzonitrile (major product, 20-22%), phenanthrene, anthracene, o,o′-dicyanodiphenyl, 9,10-anthraquinone, 2-methyl-4,5-diphenyloxazole and 1,1,2,2-tetraphenylethane. A radical- and carbene mechanism is suggested in order to rationalize the formation of the reaction products.

Generation of 1,3-chalcogenaza-1,3-butadienes by thermal cycloreversion of 2,4,6-trisubstituted 6H-1,3,5-oxachalcogenazines

1,3-Thiaza- and 1,3-selenaza- 1,3-butadienes bearing several substituents at the C-2 and C-4 positions were generated through thermal cycloreversion of 6H-1,3,5-oxathiazines or 6H-1,3,5-oxaselenazines, respectively, and the heterodienes were efficiently trapped by using acetylenic dienophiles. When 6H-1,3,5-oxathiazines or 6H-1,3,5-oxaselenazines were heated in the presence of nucleophiles, such as alcohols or thiols, the corresponding 1,4-adducts of the heterodienes with the nucleophiles were obtained in good yields. On the other hand, heating of 6H-1,3,5-oxathiazines or 6H-1,3,5-oxaselenazines in the absence of trapping agents afforded several products which originated from the in situ generated 1,3-chalcogenaza-1,3-butadienes; also the heterodienes were not isolated or observed directly as the monomeric forms at all.

Aminoketone, oxazole and thiazole synthesis. Part XIII. 1 new 2-aryl-6-phenyloxazoles with 4-methyl or 4-isopropyl groups

Benzoylation of (±)-α-alanine and (±)-valine followed by cyclization afforded the corresponding azlactones, which reacted with benzene, toluene, o- and m-xylene yielding substituted N-benzoyl-phenacylamines. Their cyclization in the presence of phosphorus oxychloride led to the title compounds whose electronic and NMR spectra (1H and 13C) are presented.

Pyrrolomorphinans as δ opioid receptor antagonists. The role of steric hindrance in conferring selectivity

A series of 2',3'-disubstituted pyrrolomorphinans (5a-i) were synthesized to determine the role of steric hindrance at μ and γ receptors in promoting δ opioid receptor antagonist selectivity. In smooth muscle preparations, five members of the series (5a-c,e,f) possessed K(e) values in the range 2-15 nM and were 6 selective. Since the unsubstituted analogue 4 possessed δ antagonist potency of similar magnitude, but was not δ selective, it is suggested that the 2',3'substitution confers δ selectivity by hindering the interaction of the pharmacophore at μ and γ receptors, while not affecting δ receptors.

Ephedrine and pseudoephedrine precursors

Preparation of novel prochiral olefinic compounds which can be asymmetrically hydrogenated to enantiomers, which are converted to ephedrine and pseudoephedrine by described procedures.