19983-35-8Relevant academic research and scientific papers
Copper-Catalyzed Thioannulation of Propynamides with Sodium Sulfide for the Synthesis of Isothiazol-3-ones
Wang, Sui-Qian,Hu, Bo-Lun,Zhang, Xing-Guo
, (2019)
A method for the copper-catalyzed thioannulation of propynamides with sodium sulfide was developed for the synthesis of isothiazol-3-ones. The reaction involves a nucleophilic addition and an intramolecular cross-dehydrogenative coupling reaction. The thi
Isothiazolin-3-one compound and preparation method thereof
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Paragraph 0027; 0064-0068, (2019/08/26)
The invention discloses an isothiazolin-3-one compound and a preparation method thereof. The method comprises the following steps that a 2-propynamide derivative is adopted as a substrate, a sulfur source, a catalyst, an oxidizing agent and a ligand sodiu
A stereoselective thiocyanate conjugate addition to electron deficient alkynes and concomitant cyclization to N,S-heterocycles
Dwivedi, Vikas,Rajesh, Manda,Kumar, Ravi,Kant, Ruchir,Sridhar Reddy, Maddi
supporting information, p. 11060 - 11063 (2017/10/13)
A regio- and stereoselective thiocyanate addition to ynones is achieved using KSCN in AcOH at 70 °C. The reaction is extendable to ynals, ynesulfones, ynoic acids and ynoates. Adducts from ynones were readily transformed into thiazine-2-thione derivatives under slightly modified reaction conditions. In contrast, thiocyanated adducts from ynamides underwent an in situ decyanative amido cyclization towards isothiazolones. None of these events needed any transition metal or catalyst, attaining a high synthetic value.
2,5-diarylisothiazolone: Novel inhibitors of cytokine-induced cartilage destruction
Wright, Stephen W.,Petraitis, Joseph J.,Freimark, Bruce,Giannaras, John V.,Pratta, Michael A.,Sherk, Susan R.,Williams, Jean M.,Magolda, Ronald L.,Arner, Elizabeth C.
, p. 851 - 858 (2007/10/03)
A series of 2,5-diarylisothiazolones is reported that inhibit the IL-1β- induced breakdown of bovine nasal septum cartilage in an organ culture assay. The synthesis and preliminary SAR of these compounds are described. These compounds represent a novel, n
