199865-36-6

Basic information

• Product Name: 3-(2-aminopyrimidin-4-yl)-1-methyl-1H-indole
• Synonyms: 3-(2-aminopyrimidin-4-yl)-1-methyl-1H-indole
• CAS NO: 199865-36-6
• Molecular Weight: 224.265
• Mol File: 199865-36-6.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 3-(2-aminopyrimidin-4-yl)-1-methyl-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-aminopyrimidin-4-yl)-1-methyl-1H-indole(199865-36-6)
• EPA Substance Registry System: 3-(2-aminopyrimidin-4-yl)-1-methyl-1H-indole(199865-36-6)

Safety Data

• Hazardous Substances Data: 199865-36-6(Hazardous Substances Data)

Upstream product

• 954421-16-0 (2E)-3-(dimethylamino)-1-(1-methyl-1H-indol-3-yl)-2-propen-1-one 
• 50-01-1 guanidine hydrochloride 
• 1169700-39-3 1-(1-methyl-1H-indol-3-yl)-3-(trimethylsilyl)prop-2-yn-1-one 
• 603-76-9 1-methylindole 
• 1032452-86-0 2-chloro-4-(1'-methyl-1H-indol-3-yl)pyrimidine 
• 3993-78-0 2-amino-4-chloropyrimidine 
• 19012-02-3 N-methyl-3-acetylindole 
• 593-85-1 diguanidine carbonate 
• 703-80-0 3-acetylindole 

Downstream Products

• 1421373-65-0 [N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide] 
• 1421373-66-1 N-(2-(N-(2-(dimethylamino)ethyl)-N-methylamino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide methanesulfonate 

Relevant articles and documents

Synthesis of aminopyrimidylindoles structurally related to meridianins

The synthesis of new meridianin derivatives substituted at the C-5′ position of the 2-aminopyrimidine ring by various aryl groups and substituted or not by a methyl group on the indole nitrogen is described. The 2-aminopyrimidine ring was obtained via a B

4-(1-methylindole-3-yl) pyrimidine derivative and application thereof

A series of 4-(1-methylindole-3-yl) pyrimidine derivatives are prepared through reasonable design by taking 4-indolyl-2-arylaminopyrimidine as a skeleton, an in-vitro anti-inflammatory activity test result shows that most of the compounds have relatively high inhibition capability on inflammatory cytokines IL-6 and IL-8, and an experimental result shows that most of the compounds have different degrees of inhibition effects on IL-6 and IL-8 induced by LPS, and the inhibition effects are basically superior to that of 4-indolyl-2-aminopyrimidine. The invention provides a certain research basis for further obtaining anti-ALI micromolecules with high anti-inflammatory activity and high bioavailability.

Consecutive three-component synthesis of ynones by decarbonylative sonogashira coupling

A study was conducted to demonstrate consecutive three-component synthesis of ynones by decarbonylative Sonogashira coupling. Sonogashira coupling started from electron-rich heterocycles and oxalyl chloride as a source of the CO building block via interme