19989-44-7

Upstream product

• 98-91-9 thiobenzoic acid 
• 1451164-67-2 C₂₆H₂₁INOP 
• 100-52-7 benzaldehyde 
• 97776-06-2 4-acetyl-2-iodoaniline 
• 15111-14-5 2-iodo-N-(phenylmethylene)-benzenamine 
• 98-88-4 benzoyl chloride 

Downstream Products

• 19989-50-5 3-dimethylamino-1-(2-phenyl-benzothiazol-6-yl)-propan-1-one; monohydrochloride 
• 19989-45-8 2-bromo-1-(2-phenyl-benzothiazol-6-yl)-ethanone 
• 19989-51-6 1-(2-phenyl-benzothiazol-6-yl)-3-piperidin-1-yl-propan-1-one; monohydrochloride 

Relevant academic research and scientific papers

Cu-catalyzed three-component synthesis of substituted benzothiazoles in water

Three in one: Copper-catalyzed three-component reactions, involving 2-iodoanilines, aldehydes, and sulfur powder, afford 2-phenylbenzothiazoles in water. A variety of 2-substituted benzothiazoles can be obtained in good to excellent yields of up to 96% (see scheme). Copyright

Method used for rapid preparation of benzo-heterocycle compound with physical grinding under solvent-free room temperature conditions

The invention discloses a method used for rapid preparation of benzo-heterocycle compound with physical grinding under solvent-free room temperature conditions. According to the method, glacial aceticacid is taken as a catalyst; at solvent-free room temperature conditions, physical grinding is adopted, reaction of 2-substituted arylamines (2-mercapto arylamine, 2-aminophenol, and o-phenylenediamine) and aromatic aldehydes is carried out using physical grinding. The method is friendly to the environment, is simple in operation, is safe, is low in cost, and is high in efficiency. Compared withthe prior art, the advantages are that: the method is suitable for a large amount of functional groups, yield is high, less by-product is generated, operation is simple, the method is safe, cost is low, and the method is friendly to the environment.

Copper-catalyzed synthesis of benzo[ b ]thiophenes and benzothiazoles using thiocarboxylic acids as a coupling partner

An efficient copper-catalyzed approach to benzo[b]thiophene and benzothiazole derivatives using thiocarboxylic acids as a sulfur source has been developed. In the presence of CuI and 1,10-phen, and n-Pr3N as the base, (2-iodobenzyl)triphenylphosphonium bromide and (2-iodophenylimino) triphenylphosphorane reacted smoothly with thiocarboxylic acids to give benzo[b]thiophene and benzothiazole derivatives in good yields via sequential Ullmann-type C-S bond coupling and Wittig condensation.