1999-88-8

Basic information

• Product Name: L-Valine, N-[N-[(phenylmethoxy)carbonyl]-L-valyl]-, methyl ester
• CAS NO: 1999-88-8
• Molecular Formula: C19H28N2O5
• Molecular Weight: 364.442
• Mol File: 1999-88-8.mol
• Article Data: 35

Chemical Properties

• CAS DataBase Reference: L-Valine, N-[N-[(phenylmethoxy)carbonyl]-L-valyl]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Valine, N-[N-[(phenylmethoxy)carbonyl]-L-valyl]-, methyl ester(1999-88-8)
• EPA Substance Registry System: L-Valine, N-[N-[(phenylmethoxy)carbonyl]-L-valyl]-, methyl ester(1999-88-8)

Safety Data

• Hazardous Substances Data: 1999-88-8(Hazardous Substances Data)

Upstream product

• 6306-52-1 L-valine methylester hydrochloride 
• 54647-77-7 N-[(benzyloxy)carbonyl]-L-valine, compound with dicyclohexylamine (1:1) 
• 79598-34-8 benzyloxycarbonylvaline hydroxyiminocyano-α-picoline ester 
• 516-06-3 D,L-valine 
• 72-18-4 L-valine 
• 57022-41-0 ZVal, triethylammonium salt 
• 4070-48-8 L-Valine methyl ester 
• 96452-48-1 benzyl pyridin-2-yl carbonate 
• 501-53-1 benzyl chloroformate 
• 10084-80-7 N^α-benzyloxycarbonyl-L-valine anhydride 
• 1149-26-4 (S)-N-(benzyloxycarbonyl)valine 
• 4070-48-8 L-valine methyl ester 
• 109745-79-1 (S)-2-(3-Cyano-4,6-dimethyl-pyridin-2-ylsulfanylamino)-3-methyl-butyric acid methyl ester 
• 96658-28-5 diethyl 2-(3-oxo-2,3-dihydro-1,2-benzisosulfonazolyl)phosphonate 

Downstream Products

• 1523536-00-6 benzyl ((S)-1-(((S)-1-hydroxy-3-methylbutan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate 
• 2471-53-6 Z-Val-Val-Val-OMe 
• 19943-16-9 (3S,6S)-3,6-bis(isopropyl)piperazine-2,5-dione 
• 19542-54-2 N-benzyloxycarbonyl-L-valyl-L-valine 
• 3918-94-3 Val-Val 
• 13795-37-4 N-(N-benzoyl-L-valyl)-L-valine methyl ester 
• 852983-16-5 Z-Val-Val-Pro-Gln(Trt)-OH 
• 852983-17-6 H-Val-Val-Pro-Gln(Trt)-OH 

Relevant articles and documents

A Sterically Overcrowded, Isopropyl-Substituted, Lanthanide-Chelating Tag for Protein Pseudocontact Shift NMR Spectroscopy: Synthesis of its Macrocyclic Scaffold and Benchmarking on Ubiquitin S57 C and hCA II S166 C

A sterically overcrowded lanthanide-chelating tag has been synthesized in order to investigate the influence on the obtained pseudocontact shifts and the anisotropic part of the magnetic susceptibility tensor compared to those of its predecessor DOTA-M8-(

Ethyl 2-Cyano-2-(hydroxyimino)acetate (Oxyma): An efficient and convenient additive used with tetramethylfluoroformamidinium hexafluorophosphate (TFFH) to replace 1-hydroxybenzotriazole (HOBt) and 1-hydroxy-7-azabenzotriazole (HOAt) during peptide synthesis

The appropriateness of ethyl 2-cyano-2-(hydroxyimino)acetate (Oxyma) as a substitute for benzotriazole-based additives, for use in the TFFH approach for peptide synthesis, is discussed in terms of its capacity to control racemization, its coupling efficiency in difficult couplings either for stepwise or segment coupling in solution- and solid-phase coupling. In addition, Boc-based solution-phase peptide synthesis and its stability in the presence of growing peptide chains were studied. Oxyma displayed remarkable results in terms of racemization depression together with impressive coupling efficiency in both solution- and solid-phase synthesis. Furthermore, Oxyma suggests a lower risk of explosion than HOBt and HOAt.

An improved aldehyde linker for the solid phase synthesis of hindered amides

A novel aldehyde dual-linker system has been developed for the solid phase synthesis of sterically hindered amides. The linker [5-(4-formyl-3- hydroxyphenoxy)pentanoic acid] exploits an intramolecular oxygen-nitrogen acyl transfer mechanism to prepare com