20002-25-9

Upstream product

• 509-14-8 tetranitromethane 
• 30923-82-1 N,N-dibenzyl-2-methylpropan-2-amine 
• 3378-72-1 N-tert-butylbenzylamine 
• 6852-58-0 N-benzylidene tert-butylamine 
• 100-52-7 benzaldehyde 

Downstream Products

• 3378-72-1 N-tert-butylbenzylamine 
• 30923-82-1 N,N-dibenzyl-2-methylpropan-2-amine 
• 95954-32-8 Benzophenon-N-benzyl-N-tert.-butyl-hydrazon 
• 91215-73-5 N-Benzyl-N-tert-butyl-hydrazin 

Relevant academic research and scientific papers

The Use of Potassium/Sodium Nitrite as a Nitrosating Agent in the Electrooxidative N-Nitrosation of Secondary Amines

We report herein on the electrochemical N-nitrosation of secondary amines using widely available sodium/potassium nitrite as a nitrosating agent. This approach not only eliminates the need for using a combination of sodium/potassium and a strong acid but also has good functional group tolerance. The reaction is compatible with the late-stage modification of pharmaceutical compounds and could be conducted in gram scale with a high reaction efficiency. Preliminary mechanistic studies indicate that the N-nitrosation occurs via the anodic oxidation of KNO2 into an NO2 radical which is then transformed into an NO+ cation.

Facile N-nitrosation of secondary amines using poly(N,N'-dibromo-Nethylene- benzene-1,3-disulfonamide) and N,N,N′,N′-tetrabromobenzene-1,3- disulfonamide/NaNO2 under mild conditions

In this research project, a combination of poly(N,N′-dibromo-N- ethylene-benzene-1,3-disulfonamide) [PBBS] and/or (N,N,N′,N′- tetrabromobenzene-1,3-disulfonamide) [TBBDA] with sodium nitrite in the presence of wet SiO2 (50% w/w) was used as an efficient nitrosating agent for the conversion of secondary amines to their corresponding nitroso compounds. N-Nitrosation reaction has been performed in dichloromethane at room temperature under mild and heterogeneous conditions. The reaction is operationally simple and corresponding products were achieved in good to excellent yields.

N-nitrosation of secondary amines using supported perchloric acid on silica gel and stereoselectivity study of nitrosated products

N-Nitrosation of different types of secondary amines has been proceeded using supported perchloric acid on silica gel and sodiume nitrite under heterogeneous conditions. The operational system is simple and high pure products can be easily isolated with good to high yields.