200190-87-0

Usage

Uses

Used in Pharmaceutical Industry:
1-Bromo-4-chloro-2-fluoro-5-methylbenzene is used as an intermediate in the synthesis of various pharmaceutical compounds for its unique halogenated structure, which can be further modified to create a range of medicinal agents with specific therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 1-Bromo-4-chloro-2-fluoro-5-methylbenzene serves as a key intermediate in the development of pesticides and other crop protection agents. Its halogenated nature allows for the creation of molecules with targeted pest control capabilities, enhancing agricultural productivity and crop protection.

InChI:InChI=1S/C7H5BrClF/c1-4-2-5(8)7(10)3-6(4)9/h2-3H,1H3

Upstream product

• 452-73-3 2-chloro-4-fluorotoluene 
• 7439-89-6 iron 

Downstream Products

• 325786-09-2 4-chloro-2-fluoro-5-methylphenylboronic acid 
• 142623-48-1 1-(4-chloro-2-fluoro-5-methylphenyl [ring-14C(U)])-1-methyl-5-(trifluoromethyl)-1H-pyrazole 
• 83803-57-0 1-bromo-4-chloro-2-methoxy-5-methylbenzene 
• 1426290-08-5 2-(5-bromo-2-chloro-4-fluorophenyl)acetonitrile 
• 333447-57-7 5-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-β-D-ribofuranosyl)-2-chloro-4-fluorotoluene 
• 333447-72-6 1,2-dideoxy-1-(4-chloro-2-fluoro-5-methylphenyl)-β-D-ribofuranose 
• 333447-56-6 5-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-α-D-ribofuranosyl)-2-chloro-4-fluorotoluene 

Relevant academic research and scientific papers

N-SULFONYL BENZAMIDE DERIVATIVE WITH HETEROCYCLIC SUBSTITUENT, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL APPLICATION THEREOF

The present invention discloses an N-sulfonyl benzamide derivative with a heterocyclic substituent, and a preparation method therefor and a pharmaceutical application thereof. More specifically, the invention discloses a compound represented by formula (II) or a pharmaceutically acceptable salt, stereoisomer, solvent compound, or prodrug thereof, and a preparation method therefor and an application thereof. Refer to the specification for definitions of each group in the formula.

POLYCYCLIC PYRAZOLINONE DERIVATIVE AND HERBICIDE COMPRISING SAME AS EFFECTIVE COMPONENT THEREOF

Provided are a polycyclic pyrazolinone derivative indicated by general formula (1) (in the formula, R1, X1, X2, X3, and Y indicate the definitions provided in the Specification) and a herbicide comprising same as effective component thereof.

PYRIMIDINE DERIVATIVES AND HERBICIDES CONTAINING THE SAME

The present invention provides a pyrimidine derivative represented by the formula: wherein R1p and R1q are the same or different, and each represents (1)hydrogen, (2)halogen, (3) a C1-6alkyl group which may be substituted or (4) a C1-6alkoxy group, and so on, R2 is halogen, a C1-6alkyl group, cyano group, and so on, Ar is a phenyl group which may be substituted or is a condensed hetero ring which may be substituted, which has excellent selective herbicidal activity, and a herbicide containing the derivative.

Synthesis of 1-(2-deoxy-β-D-ribofuranosyl)-2,4-difluoro-5- substituted-benzene thymidine mimics, some related α-anomers, and their evaluation as antiviral and anticancer agents

A group of unnatural 1-(2-deoxy-β-D-ribofuranosyl)-2.4-difluorobenzenes having a variety of C-5 substituents (H, Me, F, Cl, Br, I, CF3, CN, NO2, NH2), designed as thymidine mimics, were synthesized for evaluation as anticancer and antiviral agents. The coupling reaction of 3,5-bis-O-(p-chlorobenzoyl) 2-deoxy-α-D-ribofuranosyl chloride with an organocadmium reagent [(2,4-difluorophenyl)2Cd] afforded a mixture of the α- and β-anomeric products (α:β = 3:1 to 10:1 ratio). Treatment of the α-anomer with BF3·Et2O in nitroethane at 110-120°C for 30 min was developed as an efficient method for epimerization of the major α-anomer to the desired β-anomer. The 5-substituted (H, Me, Cl, I, NH2) β-anomers exhibited negligible cytotoxicity in a MTT assay (CC50 = 10-3-10-4 M range), relative to thymidine (CC50 = 10-3-10-5 M range), against a variety of cancer cell lines. In contrast, the 5-NO2 derivative was more cytotoxic (CC50 = 10-5-10-6 M range). A number of 5-substituted β-anomers, and some related α-anomers, that were evaluated using a wide variety of antiviral assay systems [HSV-1, HSV-2, varicella-zoster virus (VZV), vaccinia virus, vesicular stomatitis, cytomegalovirus (CMV) and human immunodeficiency (HIV-1, HIV-2) viruses], showed that this class of unnatural C-aryl nucleoside mimics are inactive antiviral agents.