20043-35-0

Upstream product

• 20043-41-8 3-p-tolyl-2⁽⁴⁾H-benzo[1,2,4]thiadiazine 1-oxide 
• 55148-72-6 2-p-tolyl-benzo[1,3]oxathiole 
• 589-18-4 4-Methylbenzyl alcohol 
• 3306-62-5 2-AMINOBENZENESULFONAMIDE 
• 104-84-7 para-methylbenzylamine 
• 99-94-5 p-Toluic acid 
• 104-87-0 4-methyl-benzaldehyde 
• 622-47-9 4-tolylacetic acid 
• 106-42-3 para-xylene 
• 7118-55-0 4-methyl-N-phenyl-benzamidine 
• 20029-42-9 1-(toluene-4-sulfonylamino)-3-p-tolyl-1λ⁴-benzo[1,2,4]thiadiazine 
• 77925-51-0 2-(N,N-diethylaminosulfonyl)nitrobenzene 
• 104-85-8 para-methylbenzonitrile 

Relevant academic research and scientific papers

Metal-free sequential dual oxidative amination of C(sp3)–H bonds: A direct approach to benzothiadiazine 1,1-dioxide derivatives

An efficient and metal-free Di-tert-butyl peroxide (DTBP)-promoted dual oxidative amination annulation of 2-amino arylsulfonamide with methylarene has been developed. This protocol provides straightforward access to benzothiadiazine 1,1-dioxide derivatives without using prefunctionalized substrates in good to excellent yields with good functional group tolerance.

Aerobic primary and secondary amine oxidation cascade by a copper amine oxidase inspired catalyst

Herein, we report a bioinspired catalytic system for the one-pot cascade oxidation of a native primary amine and anin situgenerated non-native secondary amine. The catalyst consists of ano-quinone cofactor phd (1,10-phenanthroline-5,6-dione) and a copper ion and operates under ambient air conditions. Quinazolin-4(3H)-ones, which are common pharmacophores present in numerous pharmaceuticals and bioactive compounds, were synthesized in high yields. A detailed kinetic and mechanistic study elucidates the role of the catalyst in the multi-step oxidative cascade reaction.

Transition metal-catalyzed C–H functionalization of arylacetic acids for the synthesis of benzothiadiazine 1,1-dioxides

Copper-catalyzed practical route for the synthesis of benzothiadiazine 1,1-dioxides has been developed. The method involves C–H functionalization of arylacetic acids to form aromatic aldehydes and their subsequent condensation with 2-aminobenzenesulfonami

Oxidative synthesis of quinazolinones and benzothiadiazine 1,1-dioxides from 2-aminobenzamide and 2-aminobenzenesulfonamide with benzyl alcohols and aldehydes

An interesting procedure for the zinc-catalyzed oxidative transformation of ready available 2-aminobenzamide, 2-aminobenzenesulfonamide with benzyl alcohols has been developed. Various quinazolinones and benzothiadiazine 1,1-dioxides were prepared in moderate to good yields under identical conditions. The reactions of both aromatic aldehydes and aliphatic aldehydes with 2-aminobenzamide under catalyst free conditions were described as well. In water media, the products were formed in good yields.

Ruthenium-catalysed oxidative synthesis of heterocycles from alcohols

Ruthenium-catalysed hydrogen transfer has been successfully used for the conversion of alcohols into either 2,3-dihydroquinazolines or quinazolines. The choice of reaction conditions allows for the selective formation of either heterocycle and the methodology can also be applied to the sulfonamide analogue.

Microwave-assisted direct synthesis of 4H-1,2,4-benzothiadiazine 1,1-dioxide derivatives

We describe a rapid and convenient methodology for the preparation of diverse 3-aryl and 3-trifluoromethyl 4H-1,2,4-benzothiadiazine-1,1-dioxides in a one-pot microwavepromoted reaction between 2-aminobenzenesulfonamides and benzaldehydes, trifluoroacetic acid or benzoic acids. Copyright Taylor & Francis Group, LLC.

Facile synthesis of 2H-1,2,4-benzothiadiazine 1,1-dioxides promoted by Sml2

2H-1,2,4-Benzothiadiazine 1,1-dioxides are prepared in good yields via reductive cyclisation of N,N-diethyl-o-nitrobenzenesulfonamides with appropriate nitriles promoted by Sml2 under mild and neutral conditions.