20047-50-1

Upstream product

• 80-59-1 Tiglic acid 
• 591-51-5 phenyllithium 
• 50599-02-5 2-methyl-1-phenyl-3-buten-1-one 
• 80317-46-0 α-(1-methyl-1-propenyl)benzenemethanol 
• 4461-41-0 2-chloro-but-2-ene 
• 1461-22-9 tributyltin chloride 
• 98-88-4 benzoyl chloride 
• 86633-14-9 1-methylprop-1-enyltributyltin 
• 441058-82-8 3-Hydroxy-2-methyl-1-phenyl-4-phenylselanyl-butan-1-one 
• 98-07-7 Benzotrichlorid 
• 78-93-3 butanone 
• 7204-29-7 trans-2-butenyl acetate 
• 100-51-6 benzyl alcohol 
• 6737-11-7 2-acetoxy-3-butene 

Downstream Products

• 52149-04-9 (E)-2-Methoxy-3-methyl-2-phenyl-3-penten 
• 52149-05-0 (E)-1-Methoxy-2-methyl-1-phenyl-2-buten 
• 87514-17-8 Trimethyl-((Z)-2-methyl-1-phenyl-buta-1,3-dienyloxy)-silane 
• 111300-59-5 dimethyl-3,4 phenyl-5 oxo-5 pentanedithioate de methyle 
• 111300-59-5 dimethyl-3,4 phenyl-5 oxo-5 pentanedithioate de methyle 
• 938-87-4 2-methyl-1-phenyl-butan-1-one 
• 945983-17-5 C₁₈H₁₈Cl₂O₂S 
• 102402-72-2 (E)-3-methyl-2-phenyl-1,3-pentadiene 
• 1202186-08-0 (E)-4-phenyl-3,7-dimethyl-7-(tetrahydropyran-2-yloxy)-oct-2-en-5-yn-4-ol 
• 945983-26-6 C₁₈H₁₆O₂S 
• 945983-23-3 C₁₈H₁₆OS 

Relevant academic research and scientific papers

A Convenient Method for Preparing Aromatic α,β-Unsaturated Ketones from α,β-Unsaturated Acyl Chlorides and Arylboronic Acids via Suzuki-Miyaura Type Coupling Reaction

Aromatic α,β-unsaturated ketones are synthesized efficiently by palladium-catalyzed cross-coupling reaction of arylboronic acids with α,β-unsaturated acyl chlorides in the presence of K 3PO4 hydrate in toluene.

Borane-Catalyzed Direct Asymmetric Vinylogous Mannich Reactions of Acyclic α,β-Unsaturated Ketones

Herein, we report that, by using chiral bicyclic bisborane catalysts, we have achieved the first highly regio-, diastereo-, and enantioselective direct asymmetric vinylogous Mannich reactions of acyclic α,β-unsaturated ketones. The strong Lewis acidity and steric bulk of the bisborane catalysts were essential for the observed high yields and selectivities.

PROTEIN CROSSLINKING INHIBITOR AND USE OF THE SAME

The present invention relates to: a ketone compound having transglutaminase-inhibiting activity, which is represented by the following Formula 1, 2, or 3: wherein R1 is a substituted or unsubstituted aryl or heterocyclyl group, R2, R3, and R4 are hydrogen atoms, n is 2, X is halogen, R5 and R6 independently represent a hydrogen atom or a substituted or unsubstituted C1-C10 alkyl, aryl, or aralkyl group, wherein R5 and R6 are not hydrogen atoms at the same time, or R5 and R6 may be taken together to form a saturated or unsaturated and substituted or unsubstituted heterocyclyl group containing a nitrogen atom (N); an inhibitor of protein crosslinking comprising the compound; and a composition for preventing or treating a protein-crosslinking causative disease, which comprises the compound or the protein crosslinking inhibitor.

Iridium-Catalyzed coupling reaction of primary alcohols with 2-alkynes leading to hydroacylation products

A novel iridium-catalyzed intermolecular coupling reaction of primary alcohols or aldehydes with 2-alkynes was successfully achieved with high regioselectivity to give hydroacylation products such as α,β- unsaturated ketones in good yields. The mechanistic investigation of the reaction strongly indicated that the coupling proceeds through the initial formation of homoallylic alcohols followed by dehydrogenation to β,γ-unsatutated ketones and then isomerisation, which leads to the hydroacylation products.

Hydroacylation of 2-butyne from the alcohol or aldehyde oxidation level via ruthenium catalyzed C-C bond forming transfer hydrogenation

Under the conditions of ruthenium catalyzed transfer hydrogenation, 2-butyne couples to alcohols 1a-1j to deliver α,β-unsaturated ketones 3a-3j in good to excellent isolated yields with complete E-stereoselectivity. Under identical conditions, aldehydes 2

Nickeladihydrofuran. Key intermediate for nickel-catalyzed reaction of alkyne and aldehyde

The formation of a nickeladihydrofuran by oxidative cyclization of an alkyne and an aldehyde with nickel(0) has been demonstrated; the transformation of the nickeladihydrofuran into an enone by decomposition, a lactone by carbonylation and an allylic alcohol by treatment with ZnMe2 suggests that nickeladihydrofuran is an important key intermediate in a variety of catalytic reactions. The Royal Society of Chemistry.

Difluoro-λ3-bromane-induced oxidative carbon-carbon bond-forming reactions: Ethanol as an electrophilic partner and alkynes as nucleophiles

Reported here for the first time are the oxidative couplings of alkynes and primary alcohols yielding conjugated enones. Although the BF3-catalyzed reaction of terminal alkynes with p-trifluoromethylphenyl(difluoro)-λ3-bromane results in the fluoro-λ3-bromanation of triple bonds to afford (E)-β-fluorovinyl-λ3-bromanes, reaction of an alkyne with the difluoro-λ3-bromane in the presence of an alcohol and BF3-Et2O affords directly conjugated enones in good yields. The reaction proceeds in a highly stereo- and regioselective manner under metal-free conditions. Interestingly, no formation of enones was detected, when difluoro-λ3-iodane p-CF3C6H4IF2 was used instead of the λ3-bromane. A mechanism involving a λ3-bromane-induced oxidation of an alcohol to an aldehyde, [2 + 2] cyclization with alkynes yielding 2H-oxetes, and finally the electrocyclic ring opening is discussed. Copyright

Ruthenium-Catalyzed Allylation of Primary Alcohols by Allylic Acetates: A Novel Synthesis of α,β-Unsaturated Ketones

Certain ruthenium complexes show high catalytic activity in the synthesis of α,β-unsaturated ketones from primary alcohols and allylic acetates.Here, ?-allylruthenium intermediates apparently operate as nucleophiles rather than as electrophiles.

Cathodic Addition of Benzylidyne Trichloride to Ketones and Aldehydes

Ketones are converted to homologated enones 7a-g in good yields by cathodic addition of benzylidyne trichloride (1d).As intermediates α-Chlorooxiranes 6 are assumed, which rearrange via α-keto carbenium ions 9 to enones.The intermediacy of 9 is supported by the addition of 1d to norcamphor, where the products indicate equilibrating norbornyl cations as intermediates. α,β-Unsaturated ketones lead depending on steric shielding of the double bond to the cyclopropane 23 as 1,4-adduct or the enone 26 as 1,2-adduct.With aldehydes and 1d, α-chloro or βhydroxy ketones, the conversion products of 2-chlorooxiranes, are obtained.

Synthesis of β,γ- and α,β-Unsaturated Ketones Using Allyltitanium Reagents

Carboxylic acid imidazolides (N-acylimidazoles) (4, 7a-c, 12) react with allyltitanium tris(amides) (3b, c, 10) to form β,γ-unsaturated ketones (5, 8a-c, 11a-d, 13) without carbinol formation or isomerization of the olefinic double bond.Controlled isomerization to α,β-isomers having E-configuration is possible under mild conditions using Al2O3.