20047-50-1

Basic information

• Product Name: 2-Buten-1-one, 2-methyl-1-phenyl-, (2E)-
• Synonyms: (E)-2-methyl-1-phenylbut-2-en-1-one;2-methyl-1-phenyl-2-buten-1-one;trans-Methylcrotophenon;(E)-2-Methyl-1-phenyl-but-2-en-1-one;methyl-2 phenyl-1 butene-2 one-1
• CAS NO: 20047-50-1
• Molecular Formula: C11H12O
• Molecular Weight: 160.216
• Mol File: 20047-50-1.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 243.2±13.0 °C(Predicted)
• Density: 0.977±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-Buten-1-one, 2-methyl-1-phenyl-, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Buten-1-one, 2-methyl-1-phenyl-, (2E)-(20047-50-1)
• EPA Substance Registry System: 2-Buten-1-one, 2-methyl-1-phenyl-, (2E)-(20047-50-1)

Safety Data

• Hazardous Substances Data: 20047-50-1(Hazardous Substances Data)

Upstream product

• 4461-41-0 2-chloro-but-2-ene 
• 1461-22-9 tributyltin chloride 
• 98-88-4 benzoyl chloride 
• 98-07-7 Benzotrichlorid 
• 78-93-3 butanone 
• 7204-29-7 trans-2-butenyl acetate 
• 100-51-6 benzyl alcohol 
• 6737-11-7 2-acetoxy-3-butene 
• 503-17-3 dimethylacetylene 
• 25201-44-9 2-methyl-1-phenyl-3-butene-1-ol 
• 100-52-7 benzaldehyde 
• 80317-46-0 α-(1-methyl-1-propenyl)benzenemethanol 
• 673-32-5 1-Phenylprop-1-yne 
• 64-17-5 ethanol 

Downstream Products

• 52149-04-9 (E)-2-Methoxy-3-methyl-2-phenyl-3-penten 
• 87514-17-8 Trimethyl-((Z)-2-methyl-1-phenyl-buta-1,3-dienyloxy)-silane 
• 111300-59-5 dimethyl-3,4 phenyl-5 oxo-5 pentanedithioate de methyle 
• 111300-59-5 dimethyl-3,4 phenyl-5 oxo-5 pentanedithioate de methyle 
• 945983-23-3 C₁₈H₁₆OS 
• 945983-26-6 C₁₈H₁₆O₂S 
• 102402-72-2 (E)-3-methyl-2-phenyl-1,3-pentadiene 
• 1202186-08-0 (E)-4-phenyl-3,7-dimethyl-7-(tetrahydropyran-2-yloxy)-oct-2-en-5-yn-4-ol 
• 945983-17-5 C₁₈H₁₈Cl₂O₂S 
• 938-87-4 2-methyl-1-phenyl-butan-1-one 
• 52149-05-0 (E)-1-Methoxy-2-methyl-1-phenyl-2-buten 

Relevant articles and documents

A Convenient Method for Preparing Aromatic α,β-Unsaturated Ketones from α,β-Unsaturated Acyl Chlorides and Arylboronic Acids via Suzuki-Miyaura Type Coupling Reaction

Aromatic α,β-unsaturated ketones are synthesized efficiently by palladium-catalyzed cross-coupling reaction of arylboronic acids with α,β-unsaturated acyl chlorides in the presence of K 3PO4 hydrate in toluene.

PROTEIN CROSSLINKING INHIBITOR AND USE OF THE SAME

The present invention relates to: a ketone compound having transglutaminase-inhibiting activity, which is represented by the following Formula 1, 2, or 3: wherein R1 is a substituted or unsubstituted aryl or heterocyclyl group, R2, R3, and R4 are hydrogen atoms, n is 2, X is halogen, R5 and R6 independently represent a hydrogen atom or a substituted or unsubstituted C1-C10 alkyl, aryl, or aralkyl group, wherein R5 and R6 are not hydrogen atoms at the same time, or R5 and R6 may be taken together to form a saturated or unsaturated and substituted or unsubstituted heterocyclyl group containing a nitrogen atom (N); an inhibitor of protein crosslinking comprising the compound; and a composition for preventing or treating a protein-crosslinking causative disease, which comprises the compound or the protein crosslinking inhibitor.

Hydroacylation of 2-butyne from the alcohol or aldehyde oxidation level via ruthenium catalyzed C-C bond forming transfer hydrogenation

Under the conditions of ruthenium catalyzed transfer hydrogenation, 2-butyne couples to alcohols 1a-1j to deliver α,β-unsaturated ketones 3a-3j in good to excellent isolated yields with complete E-stereoselectivity. Under identical conditions, aldehydes 2