20069-28-7

Basic information

• Product Name: (PYRROLIDIN-1-YLCARBONOTHIOYL)THIO]ACETIC ACID
• Synonyms: 2-(pyrrolidine-1-carbothioylsulfanyl)acetate
• CAS NO: 20069-28-7
• Molecular Formula: C₇H₁₁NO₂S₂
• Molecular Weight: 205.301
• Mol File: 20069-28-7.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 353.6°C at 760 mmHg
• Flash Point: 167.6°C
• Appearance: /
• Density: 1.425g/cm³
• Vapor Pressure: 5.99E-06mmHg at 25°C
• Refractive Index: 1.652
• CAS DataBase Reference: (PYRROLIDIN-1-YLCARBONOTHIOYL)THIO]ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (PYRROLIDIN-1-YLCARBONOTHIOYL)THIO]ACETIC ACID(20069-28-7)
• EPA Substance Registry System: (PYRROLIDIN-1-YLCARBONOTHIOYL)THIO]ACETIC ACID(20069-28-7)

Safety Data

• Hazardous Substances Data: 20069-28-7(Hazardous Substances Data)

Usage

General Description

(PYRROLIDIN-1-YLCARBONOTHIOYL)THIO]ACETIC ACID is a chemical compound with a complex and unique structure. It contains a pyrrolidine ring, which is a five-membered nitrogen-containing ring, as well as a thioacetate group. The presence of the thio group indicates that it contains a sulfur atom, which can affect its reactivity and properties. (PYRROLIDIN-1-YLCARBONOTHIOYL)THIO]ACETIC ACID may have potential applications in the field of organic synthesis, pharmaceuticals, or material science due to its unique structure and potential reactivity. However, further research and testing would be needed to fully understand its properties and potential uses.

InChI:InChI=1/C7H11NO2S2/c9-6(10)5-12-7(11)8-3-1-2-4-8/h1-5H2,(H,9,10)

Upstream product

• 123-75-1 pyrrolidine 
• 75-15-0 carbon disulfide 
• 3926-62-3 sodium monochloroacetic acid 
• 79-11-8 chloroacetic acid 
• 109-01-3 1-methyl-piperazine 

Downstream Products

• 135327-52-5 triphenyl(N,N-tetramethylenethiocarbamoylthioacetato-O)tin 
• 193208-37-6 2-pyrrolidino-5-phenyl-6H-1,3,4-thiadiazine hydrobromide 

Relevant articles and documents

Ensembling three multicomponent reactions for the synthesis of a novel category of pseudo-peptides containing dithiocarbamate and N,X-heterocylic groups

Consecutive multicomponent reactions have been applied for the synthesis of novel pseudo-peptides bearing dithiocarbamate and N,X-heterocyclic groups (X = S, O) in only one structure. The first multicomponent reaction includes the synthesis of dithiocarbamates using an amine or amino acid, CS2 and an electrophile. The second MCR is synthesis of Asinger imines using 2-chloroisobutyraldehyde, NaXH (X = S, O), ketone and ammonia. The final MCR is Ugi reaction to afford the corresponding three-dimensional pseudo-peptides. Various Asinger imines, carboxylic acids and isocyanides were applied in this protocol to provide diversities of pseudo-peptides in high to excellent yields.

Synthesis and reactivity of 2-pyrrolidino-, 2-N-methylpiperazino-, 2-piperidino-, and 2-morpholino-1,3,4-thiadiazines

A variety of 2-pyrrolidino-, 2-N-methylpiperazino-, 2-piperidino-, and 2-morpholino-1,3,4-thiadiazines were prepared by cyclocondensation of phenacyl halides with thiosemicarbazides. Heating of the products resulted in desulfurization and formation of pyrazoles. The rate of this process strongly depends on the substitution pattern of the 1,3,4-thiadiazines.

Synthesis, spectral studies and antiamoebic activity of new 1-N-substituted thiocarbamoyl-3-phenyl-2-pyrazolines

Thirty new pyrazoline derivatives were synthesized by cyclization of Mannich bases with thiosemicarbazides being substituted by different cyclic and aromatic amines. The structures of the compounds were elucidated by elemental analyses, UV, IR, 1H and 13C NMR and ESI-MS spectral data. The in vitro antiamoebic activity was evaluated against Entamoeba histolytica in comparison with metronidazole used as reference substance. Out of the 30 compounds screened for antiamoebic activity, 10 (5, 6, 15, 18, 25-30) were found to be better inhibitors of E. histolytica since they showed lesser IC50 values than metronidazole. The preliminary results indicated that the presence of 3-chloro or 3-bromo substituent on the phenyl ring at position 3 of the pyrazoline ring enhanced the antiamoebic activity as compared to unsubstituted phenyl ring. The study suggests that the preliminary activity of these compounds may further be explored for the development of new targets for amoebiasis.