200726-78-9Relevant articles and documents
Synthesis and in vitro evaluation of novel highly potent coumarin inhibitors of gyrase B
Laurin, Patrick,Ferroud, Didier,Klich, Michel,Dupuis-Hamelin, Claudine,Mauvais, Pascale,Lassaigne, Patrice,Bonnefoy, Alain,Musicki, Branislav
, p. 2079 - 2084 (1999)
The design, synthesis, and in vitro biological activity of a series of novel coumarin inhibitors of gyrase B is presented. Replacement of the 3- acylamino residue (3-NHCOR) of coumarin drags with reversed isosteres C(=O)R, C(=N-OR)R', COOR, CONHR and CONH