Bioorganic and Medicinal Chemistry Letters p. 2079 - 2084 (1999)
Update date:2022-09-26
Topics:
Laurin, Patrick
Ferroud, Didier
Klich, Michel
Dupuis-Hamelin, Claudine
Mauvais, Pascale
Lassaigne, Patrice
Bonnefoy, Alain
Musicki, Branislav
The design, synthesis, and in vitro biological activity of a series of novel coumarin inhibitors of gyrase B is presented. Replacement of the 3- acylamino residue (3-NHCOR) of coumarin drags with reversed isosteres C(=O)R, C(=N-OR)R', COOR, CONHR and CONH
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