2008-09-5

Usage

Class

Benzoxazole derivatives It belongs to a group of compounds that are derived from benzoxazole, which is a five-membered heterocyclic ring system.

Structure

Two benzoxazole rings connected by a 2-(1,3-benzoxazol-2-yl)ethyl group The compound features a unique arrangement of two benzoxazole rings linked together by an ethyl group substituted with a 1,3-benzoxazole moiety.

Potential applications

Pharmaceutical and materials science Due to its distinctive structure and properties, this chemical may be used in the development of new drugs and advanced materials.

Building block in organic synthesis

The compound can be utilized as a starting material or intermediate in the synthesis of more complex organic compounds, contributing to the development of novel molecules with various applications.

Fluorescent probe for biomedical imaging

The chemical's unique structure may allow it to be used as a fluorescent probe, which can help visualize and study biological processes and structures in medical research and diagnostics.

Further research and development

Ongoing investigation and development of 2-[2-(1,3-benzoxazol-2-yl)ethyl]-1,3-benzoxazole may lead to the discovery of new applications and uses, expanding its potential impact on various fields.

Upstream product

• 110-15-6 succinic acid 
• 95-55-6 2-amino-phenol 
• 123-25-1 succinic acid diethyl ester 
• 52426-61-6 succinodiimidic acid diethyl ester; dihydrochloride 
• 108-30-5 succinic acid anhydride 

Relevant academic research and scientific papers

Head-to-head bisbenzazole derivatives as antiproliferative agents: design, synthesis, in vitro activity, and SAR analysis

Abstract: In the present work, a series of bisbenzazole derivatives were designed and synthesized as antiproliferative agents. The antiproliferative activity of these compounds was investigated using MTT assay. Bisbenzazole derivatives showed significant antiproliferative activity against all the four tested cancer cell lines. Among the various bisbenzazole derivatives, bisbenzoxazole derivatives exhibited the most promising anticancer activity followed by bisbenzimidazole and bisbenzothiazole derivatives. All the derivatives were found to be less toxic as compared to methotrexate (positive control) in normal human cells, indicating selective and efficient antiproliferative activity of these bisbenzazole derivatives. The structure–activity relationships of heteroaromatic systems and linkers present in bisbenzazole derivatives were analyzed in detail. In silico ADMET prediction revealed that bisbenzazole is a drug-like small molecule with a favorable safety profile. Compound 31 is a potential antiproliferative hit compound that exhibits unique cytotoxic activity distinct from methotrexate. Graphic abstract: Twenty-one bisbenzoxazole derivatives have been designed synthesized and evaluated to be an antiproliferative activity against four human tumor cell lines.[Figure not available: see fulltext.]

Ti (IV) complexes of some heterocyclic ligands synthesis, characterization and ethylene polymerization activity

31 complexes of bis - (benzimidazole, benzothiazole and benzoxazole) compounds with Ti (IV) metal centers were synthesized, characterized, activated with methylalumoxane (MAO) and then tested for catalytic ethylene polymerization. The activities of the various catalysts were found to be functions of the hetero atoms in the ligand frameworks. The highest activity was obtained with 39/MAO (573 kg PE/mol cat. h). The produced polyethylenes showed high molecular weights (up to 1.5 × 106 g/mol) and broad molecular weight distributions (PD = 65). This could result from different interactions of the MAO counterion with the heteroatoms of the catalyst ligand generating different active sites.

Zr(IV) complexes of some heterocyclic ligands: Synthesis, characterization, and ethylene polymerization activity

Thirty-one complexes of bis-(benzimidazole, benzothiazole, and benzoxazole) compounds with Zr(IV) metal centers were synthesized, characterized, activated with methylaluminoxane (MAO), and then tested for catalytic ethylene polymerization. The activities of the various catalysts were found to be functions of the heteroatoms in the ligand frameworks and the structure around the active metal center. The highest activity was obtained with 38/MAO (424 kg E/mol cat. h). The produced polyethylenes showed high molecular weights (41/MAO, 1.9 × 106 g/mol) and broad molecular weight distributions (38/MAO, Mw = 9.64 × 105 g/mol, PD = 23). This could result from different interactions of the MAO counter ion with the heteroatoms of the catalyst ligand generating different active sites.

Microwave-assisted direct synthesis of 2-substituted benzoxazoles from carboxylic acids under catalyst and solvent-free conditions

A direct coupling of carboxylic acids with 2-aminophenol under microwave irradiation has been achieved leading to the synthesis of 2-substituted benzoxazoles under metal and solvent-free conditions. Aliphatic, aromatic and heteroaromatic carboxylic acids provide good yields. Benzoxazole formation takes place in the presence of chloro, methoxy, phenoxy, thiophenoxy, and α,β-unsaturated functionalities. In the case of dicarboxylic acids, the reaction proceeds via the formation of the corresponding anhydride with predominant formation of the mono-benzoxazole. Georg Thieme Verlag Stuttgart.